Recombinant PREB 抗体
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北京 101111
Quick Overview for Recombinant PREB 抗体 (ABIN7882037)
抗原
See all PREB 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PREB Antibody / Prolactin regulatory element binding protein
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human PREB was used as the immunogen for the PREB antibody.
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亚型
- IgG
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anti-Prolactin Regulatory Element Binding (PREB) antibody
PREB 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Prolactin Regulatory Element Binding (PREB) antibodyKD Validated PREB 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB4240 unconjugated Recombinant Antibody
anti-Prolactin Regulatory Element Binding (PREB) (AA 98-283) antibodyPREB 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Prolactin Regulatory Element Binding (PREB) (AA 140-189) antibodyPREB 适用: 人, 小鼠, 大鼠, Cow, 马, Pig, 兔, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prolactin Regulatory Element Binding (PREB) (N-Term) antibodyPREB 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prolactin Regulatory Element Binding (PREB) (N-Term) antibodyPREB 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prolactin Regulatory Element Binding (PREB) (AA 51-150) antibodyPREB 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PREB antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PREB antibody at -20oC.
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- PREB (Prolactin Regulatory Element Binding (PREB))
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别名
- PREB
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背景
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PREB antibody detects prolactin regulatory element binding protein, a transcription factor involved in gene regulation and vesicular trafficking. PREB contains WD-repeat domains that facilitate protein-protein interactions, allowing it to function as a transcriptional regulator and vesicle-associated factor. It is expressed in a variety of tissues, with high levels in brain, pituitary, and pancreas, underscoring its multifunctional roles in development and physiology.
Research using PREB antibody has revealed two primary functions of the protein. First, PREB binds to promoter elements of the prolactin gene, regulating hormone expression in the anterior pituitary. By influencing prolactin secretion, PREB impacts reproductive biology, lactation, and endocrine homeostasis. Second, PREB is associated with vesicular transport machinery, where it facilitates protein trafficking between the endoplasmic reticulum and Golgi apparatus. This dual role positions PREB as a regulator of both transcription and intracellular trafficking.
In developmental biology, PREB has been shown to be essential for embryogenesis and organogenesis. Knockout models reveal that PREB deficiency leads to embryonic lethality, indicating its necessity for proper gene regulation and cellular organization. Heterozygous models display neurological and metabolic abnormalities, linking PREB to central nervous system development and energy balance.
PREB has also been studied in the context of neurological and metabolic disorders. Altered PREB expression affects neuroendocrine regulation and insulin secretion. Dysregulation of vesicular trafficking involving PREB has implications for protein misfolding diseases and diabetes. In cancer research, PREB expression changes have been linked to tumor progression, although its exact role remains under investigation.
Antibodies against PREB are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents allow researchers to study nuclear localization, promoter occupancy, and trafficking-related functions. Clone-based antibodies ensure specificity and reproducibility across experimental systems.
NSJ Bioreagents supplies this PREB antibody for research into transcriptional regulation, neuroendocrine biology, and vesicular trafficking. -
UniProt
- Q9HCU5
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途径
- ER-Nucleus Signaling
抗原
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