Recombinant PTBP2 抗体
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北京 101111
Quick Overview for Recombinant PTBP2 抗体 (ABIN7882002)
抗原
See all PTBP2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PTBP2 Antibody / Polypyrimidine tract binding protein 2
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human PTBP2 was used as the immunogen for the PTBP2 antibody.
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亚型
- IgG
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anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) (AA 1-280) antibody
PTBP2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) antibodyPTBP2 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) (AA 1-504) antibodyPTBP2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 小鼠 Monoclonal 13D11 unconjugated
anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) (AA 1-532) antibodyPTBP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D10-B2 unconjugated
anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) (AA 1-504) antibodyPTBP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) (AA 35-175) antibodyPTBP2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) (Internal Region) antibodyPTBP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) antibodyPTBP2 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB815 unconjugated Recombinant Antibody
anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) (AA 1-504) antibodyPTBP2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 小鼠 Monoclonal 8F11 unconjugated
anti-Polypyrimidine Tract Binding Protein 2 (PTBP2) (AA 1-532) antibodyPTBP2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PTBP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PTBP2 antibody at -20oC.
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- PTBP2 (Polypyrimidine Tract Binding Protein 2 (PTBP2))
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别名
- PTBP2
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背景
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PTBP2 antibody detects polypyrimidine tract binding protein 2, an RNA-binding protein that regulates alternative splicing, mRNA transport, and neuronal differentiation. PTBP2, also known as nPTB, belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and contains four RNA recognition motifs that bind CU-rich elements in pre-mRNA. It is expressed predominantly in neurons and testes, where it orchestrates tissue-specific splicing programs.
Research using PTBP2 antibody demonstrates its central role in neuronal development. During neurogenesis, PTBP2 replaces PTBP1 in post-mitotic neurons, reprogramming splicing to promote synaptic maturation and axonal growth. Knockdown of PTBP2 disrupts neuronal differentiation, leading to defective synapse formation and impaired connectivity. Conditional knockout models confirm PTBP2's requirement for brain development, learning, and memory.
In disease contexts, PTBP2 dysregulation has been linked to neurological and reproductive disorders. Aberrant PTBP2 expression alters splicing of genes essential for synaptic signaling, contributing to autism spectrum disorders, intellectual disability, and epilepsy. In spermatogenesis, PTBP2 regulates transcripts critical for germ cell development, and its loss results in male infertility.
Cancer studies have also implicated PTBP2 in tumor progression. In gliomas and other cancers, PTBP2 expression modulates alternative splicing of oncogenes and tumor suppressors, altering cell proliferation and survival. By influencing splicing choices, PTBP2 may contribute to cancer cell adaptability and therapy resistance.
PTBP2 is also a promising target for therapeutic intervention. Manipulating PTBP2 activity or expression has been explored in reprogramming strategies, where suppression of PTBP2 promotes direct conversion of glial cells into functional neurons. Such approaches have potential applications in regenerative medicine and treatment of neurodegenerative disorders.
Antibodies against PTBP2 are validated for western blot, immunohistochemistry, immunofluorescence, and RNA immunoprecipitation. These reagents enable detection of PTBP2 expression patterns and its association with neuronal transcripts. Clone-based antibodies ensure high specificity across developmental and disease models.
NSJ Bioreagents supplies this PTBP2 antibody for research into RNA regulation, neuronal differentiation, and disease biology. -
UniProt
- Q9UKA9
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途径
- Ribonucleoprotein Complex Subunit Organization, SARS-CoV-2 Protein Interactome
抗原
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