Recombinant PCBP2 抗体
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北京 101111
Quick Overview for Recombinant PCBP2 抗体 (ABIN7881993)
抗原
See all PCBP2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PCBP2 Antibody / Poly(rC)-binding protein 2
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human PCBP2 was used as the immunogen for the PCBP2 antibody.
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亚型
- IgG
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anti-Poly(rC) Binding Protein 2 (PCBP2) (AA 1-362) antibody
PCBP2 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 5F12 unconjugated
anti-Poly(rC) Binding Protein 2 (PCBP2) (AA 1-130) antibodyPCBP2 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poly(rC) Binding Protein 2 (PCBP2) antibodyPCBP2 适用: 人 WB, IF, ICC, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Poly(rC) Binding Protein 2 (PCBP2) (AA 1-362) antibodyPCBP2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6B6 unconjugated
anti-Poly(rC) Binding Protein 2 (PCBP2) (AA 1-362) antibodyPCBP2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3A1 unconjugated
anti-Poly(rC) Binding Protein 2 (PCBP2) antibodyKD Validated PCBP2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2110 unconjugated Recombinant Antibody
anti-Poly(rC) Binding Protein 2 (PCBP2) (AA 197-276) antibodyPCBP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Poly(rC) Binding Protein 2 (PCBP2) (Middle Region) antibodyPCBP2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poly(rC) Binding Protein 2 (PCBP2) antibodyPCBP2 适用: 人, 小鼠, 斑马鱼 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poly(rC) Binding Protein 2 (PCBP2) (AA 1-363) antibodyPCBP2 适用: 人 WB, ELISA, IF, IHC, IHC (p), RNAi 宿主: 小鼠 Monoclonal 5F12 unconjugated
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应用备注
- Optimal dilution of the PCBP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PCBP2 antibody at -20oC.
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- PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))
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别名
- PCBP2
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背景
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PCBP2 antibody detects poly(rC)-binding protein 2, an RNA-binding protein that regulates mRNA stability, translation, and alternative splicing. PCBP2 belongs to the heterogeneous nuclear ribonucleoprotein K-homology domain family and binds poly(C)-rich RNA sequences, influencing post-transcriptional control of numerous transcripts. PCBP2 is widely expressed and has essential functions in iron metabolism, viral replication, and gene expression regulation.
Research using PCBP2 antibody has revealed the protein's multifunctional nature. In iron homeostasis, PCBP2 acts as a cytosolic iron chaperone, delivering iron to ferritin for storage and supporting enzymatic cofactors. Its role in viral biology is equally significant: PCBP2 has been shown to bind viral RNA, regulating replication of poliovirus, hepatitis C virus, and enteroviruses. In addition, PCBP2 can function as a negative regulator of antiviral signaling, making it an attractive target in infection research.
In cancer, PCBP2 expression is frequently dysregulated. Overexpression can promote tumorigenesis by stabilizing oncogenic transcripts and influencing signaling pathways. Conversely, loss of PCBP2 disrupts iron metabolism and RNA processing, contributing to genomic instability. Its widespread regulatory functions make it relevant for studies across oncology, virology, and metabolism.
Antibodies against PCBP2 are validated for western blot, immunoprecipitation, immunofluorescence, and immunohistochemistry. These tools allow researchers to examine PCBP2's role in RNA binding, protein interactions, and cellular localization. Clone-based antibodies ensure reliable specificity when distinguishing PCBP2 from other PCBP family members.
NSJ Bioreagents offers this PCBP2 antibody for research in RNA biology, viral replication, and cancer. -
UniProt
- Q15366
抗原
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