Recombinant PEPD 抗体
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北京 101111
Quick Overview for Recombinant PEPD 抗体 (ABIN7881913)
抗原
See all PEPD 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PEPD Antibody / Peptidase D
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human PRD was used as the immunogen for the PEPD antibody.
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亚型
- IgG
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anti-Peptidase D (PEPD) (AA 1-493) antibody
PEPD 适用: 人 WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 1D5-H3 unconjugated
anti-Peptidase D (PEPD) antibodyKD Validated PEPD 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB2830 unconjugated Recombinant Antibody
anti-Peptidase D (PEPD) (AA 1-493) antibodyPEPD 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Peptidase D (PEPD) (AA 258-395) antibodyPEPD 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidase D (PEPD) antibodyPEPD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidase D (PEPD) (AA 359-408) antibodyPEPD 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Pig, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Peptidase D (PEPD) (AA 364-398) antibodyPEPD 适用: 人 WB 宿主: 兔 Polyclonal RB55146 unconjugated
anti-Peptidase D (PEPD) (AA 1-493) antibodyPEPD 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Peptidase D (PEPD) (AA 288-424) antibodyPEPD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidase D (PEPD) (AA 231-280) antibodyPEPD 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 斑马鱼, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PEPD antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PEPD antibody at -20oC.
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- PEPD (Peptidase D (PEPD))
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别名
- PEPD
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背景
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PEPD antibody recognizes peptidase D, a cytosolic metallopeptidase responsible for hydrolyzing dipeptides with proline at the carboxyl terminus. This enzyme plays an important role in collagen metabolism, recycling proline-containing peptides into free amino acids for cellular reuse. PEPD is expressed widely in human tissues, particularly in fibroblasts and connective tissues, reflecting its role in extracellular matrix maintenance.
Research using PEPD antibody has revealed multiple functional roles beyond collagen turnover. PEPD acts as a ligand for epidermal growth factor receptor (EGFR), activating signaling cascades that regulate cell growth and survival. This dual enzymatic and signaling capacity highlights PEPD as a multifunctional protein. In cancer biology, PEPD has been linked to tumor progression, where altered expression can support both metabolic adaptation and proliferative signaling. Elevated levels of PEPD have been reported in several tumor types, suggesting its potential as a biomarker.
In hereditary diseases, mutations in PEPD cause prolidase deficiency, a rare autosomal disorder characterized by impaired collagen recycling, chronic skin ulcers, developmental delay, and immune dysfunction. Detecting PEPD levels with antibodies is important for research into this disorder as well as related connective tissue diseases. PEPD has also been associated with cardiovascular disease, where its enzymatic activity influences extracellular matrix remodeling and vascular health.
Validated antibodies against PEPD are applied in western blot, immunohistochemistry, ELISA, and immunofluorescence. These reagents enable quantification of protein expression, detection of tissue-specific localization, and evaluation of signaling roles in EGFR-related pathways. Clone-based PEPD antibodies provide consistency required for both mechanistic studies and biomarker research.
NSJ Bioreagents provides this PEPD antibody for applications in metabolism, connective tissue biology, oncology, and rare disease research. -
UniProt
- P12955
抗原
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