Recombinant PALLD 抗体
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北京 101111
Quick Overview for Recombinant PALLD 抗体 (ABIN7881899)
抗原
See all PALLD 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PALLD Antibody / Palladin
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Palladin was used as the immunogen for the PALLD antibody.
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亚型
- IgG
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anti-Palladin, Cytoskeletal Associated Protein (PALLD) antibody
PALLD 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Palladin, Cytoskeletal Associated Protein (PALLD) (AA 383-672) antibodyPALLD 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Palladin, Cytoskeletal Associated Protein (PALLD) (AA 1137-1383) antibodyPALLD 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Palladin, Cytoskeletal Associated Protein (PALLD) (Internal Region) antibodyPALLD 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Palladin, Cytoskeletal Associated Protein (PALLD) (AA 775-839) antibodyPALLD 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Palladin, Cytoskeletal Associated Protein (PALLD) (AA 895-907) antibodyVerified PALLD 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Palladin, Cytoskeletal Associated Protein (PALLD) (AA 75-125) antibodyPALLD 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PALLD antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PALLD antibody at -20oC.
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- PALLD (Palladin, Cytoskeletal Associated Protein (PALLD))
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别名
- PALLD
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背景
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PALLD antibody detects Palladin, encoded by the PALLD gene. Palladin is a cytoskeletal protein that plays a central role in actin organization, cell migration, and adhesion. It functions as a scaffold that links actin filaments to signaling molecules and structural proteins, helping cells maintain shape and mobility. PALLD antibody provides researchers with an important reagent to study cytoskeletal remodeling, development, and cancer progression.
Palladin is expressed in many tissues and exists in multiple isoforms generated by alternative splicing. Research using PALLD antibody has shown that it localizes to stress fibers, focal adhesions, and cell junctions, where it promotes actin crosslinking and interaction with other actin-binding proteins. This scaffolding role is essential for coordinated cytoskeletal dynamics during development, wound healing, and tissue remodeling.
In cancer biology, Palladin has emerged as a driver of tumor invasion and metastasis. Studies with PALLD antibody have demonstrated that elevated expression enhances actin remodeling, enabling cancer cells to migrate and invade surrounding tissues. In pancreatic cancer, Palladin is strongly upregulated, where it promotes formation of invasive protrusions. Conversely, depletion of Palladin reduces tumor cell motility and invasiveness, underscoring its pathogenic role.
Beyond oncology, Palladin is important for embryonic development and organogenesis. Research using PALLD antibody has revealed that knockout of Palladin in mice results in embryonic lethality due to defects in organ and vascular formation. Its role in fibroblast function, extracellular matrix remodeling, and smooth muscle contractility further emphasizes its significance in development and physiology.
PALLD antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting demonstrates multiple isoforms, immunohistochemistry shows tissue distribution, and immunofluorescence reveals colocalization with actin filaments. These applications make PALLD antibody indispensable for studies of cytoskeletal structure and signaling.
By supplying validated PALLD antibody reagents, NSJ Bioreagents supports research into actin biology, cancer progression, and development. Detection of Palladin provides a means to study how cytoskeletal scaffolding proteins regulate cellular architecture and disease. -
UniProt
- Q8WX93
抗原
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