Recombinant NUP107 抗体
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北京 101111
Quick Overview for Recombinant NUP107 抗体 (ABIN7881860)
抗原
See all NUP107 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- NUP107 Antibody / Nucleoporin 107
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Nup107 was used as the immunogen for the NUP107 antibody.
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亚型
- IgG
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anti-Nucleoporin 107kDa (NUP107) (AA 1-66) antibody
NUP107 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 107kDa (NUP107) antibodyNUP107 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB155 unconjugated Recombinant Antibody
anti-Nucleoporin 107kDa (NUP107) (Internal Region) antibodyVerified NUP107 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Nucleoporin 107kDa (NUP107) (Internal Region) antibodyNUP107 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 107kDa (NUP107) antibodyNUP107 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Nucleoporin 107kDa (NUP107) (AA 398-425) antibodyNUP107 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB20191 unconjugated
anti-Nucleoporin 107kDa (NUP107) (N-Term) antibodyVerified NUP107 适用: Saccharomyces cerevisiae WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Nucleoporin 107kDa (NUP107) (AA 766-925) antibodyNUP107 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 107kDa (NUP107) (AA 554-784) antibodyNUP107 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 107kDa (NUP107) (C-Term) antibodyNUP107 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NUP107 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the NUP107 antibody at -20oC.
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- NUP107 (Nucleoporin 107kDa (NUP107))
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别名
- NUP107
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背景
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NUP107 antibody detects Nuclear pore complex protein Nup107, encoded by the NUP107 gene. Nup107 is a core scaffold protein of the nuclear pore complex, the large multiprotein structure that spans the nuclear envelope and mediates nucleocytoplasmic transport. This protein is part of the Nup107 160 subcomplex, which is required for nuclear pore assembly, maintenance, and cell cycle regulated dynamics. NUP107 antibody enables detection of this essential nuclear pore component in studies of transport, nuclear envelope biology, and cell cycle control.
Nuclear pore complex protein Nup107 participates in the bidirectional transport of macromolecules, including mRNA, ribonucleoproteins, and proteins with nuclear localization or export signals. The Nup107 complex acts as a scaffold for pore assembly and contributes to nuclear envelope reformation after mitosis. Research using NUP107 antibody has revealed that disruption of this subunit leads to defective pore assembly, impaired nucleocytoplasmic trafficking, and cell cycle arrest. Its fundamental role in nuclear structure makes it indispensable for normal cell physiology.
Mutations or reduced expression of NUP107 have been linked to human disease, particularly nephrotic syndrome and premature ovarian failure. These conditions arise from defective nuclear pore assembly, underscoring the importance of this protein in development and tissue homeostasis. Studies with NUP107 antibody have also associated its dysfunction with cancers, where altered transport may affect oncogene regulation and DNA repair pathways. By examining Nup107 expression, researchers can better understand how nuclear pore biology intersects with human disease.
NUP107 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry. Western blotting reveals protein levels in dividing cells, while immunofluorescence shows localization at the nuclear envelope throughout interphase and redistribution during mitosis. Immunohistochemistry highlights expression in kidney, ovary, and other tissues affected by Nup107 mutations. These applications demonstrate the utility of NUP107 antibody in diverse cell biology and pathology research.
By supplying validated NUP107 antibody reagents, NSJ Bioreagents enables investigation of nuclear pore biology, transport mechanisms, and disease associated defects. Detection of Nuclear pore complex protein Nup107 provides a critical means of understanding how nuclear transport supports cellular life and contributes to pathology when disrupted. -
UniProt
- P57740
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途径
- Protein targeting to Nucleus
抗原
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