Recombinant NOLC1 抗体
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北京 101111
Quick Overview for Recombinant NOLC1 抗体 (ABIN7881847)
抗原
See all NOLC1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- NOLC1 Antibody / Nucleolar and coiled-body phosphoprotein 1 / NOPP140
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human NOLC1 was used as the immunogen for the NOLC1 antibody.
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亚型
- IgG
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anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (AA 590-699) antibody
NOLC1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6B4 unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (C-Term) antibodyNOLC1 适用: 人, 小鼠, 大鼠, 犬, Drosophila melanogaster, Arabidopsis WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (C-Term) antibodyNOLC1 适用: 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 犬, 山羊, 马, 斑马鱼, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (AA 590-699) antibodyNOLC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) antibodyNOLC1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB490 unconjugated Recombinant Antibody
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (AA 1-700) antibodyNOLC1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (C-Term) antibodyNOLC1 适用: 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 犬, 山羊, 马, 斑马鱼, Drosophila melanogaster, Bat, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (C-Term) antibodyNOLC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (AA 400-699) antibodyNOLC1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1) (pThr986) antibodyKD Validated NOLC1 适用: 人 WB 宿主: 兔 Monoclonal 25GB7985 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the NOLC1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the NOLC1 antibody at -20oC.
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- NOLC1 (Nucleolar and Coiled-Body Phosphoprotein 1 (NOLC1))
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别名
- NOLC1
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背景
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NOLC1 antibody detects nucleolar and coiled-body phosphoprotein 1, encoded by the NOLC1 gene. This protein is also called NOPP140, nuclear phosphoprotein 140, and hNOPP140. NOLC1 is a nucleolar protein that shuttles between the nucleolus and cytoplasm, functioning as a phosphoprotein involved in ribosome biogenesis, rRNA transcription, and nucleolar organization. Structurally, NOLC1 contains multiple serine-rich regions that undergo phosphorylation, regulating its localization and interactions with RNA polymerase I and ribosomal proteins.
NOLC1 antibody is widely applied in cell biology, cancer research, and nucleolar studies. By detecting NOLC1, researchers can investigate how the nucleolus coordinates ribosome production and stress responses. The protein is highly expressed in proliferating cells, linking it to growth and transformation. Dysregulated NOLC1 expression has been reported in cancers, where nucleolar function is often enhanced to meet elevated translational demands.
Applications of NOLC1 antibody include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blot assays detect phosphorylated and unphosphorylated isoforms, immunohistochemistry maps expression in tumors, and immunofluorescence highlights nucleolar localization and dynamics. These approaches provide powerful tools for studying nucleolar biology in health and disease.
NOLC1 interacts with RNA polymerase I transcription machinery, fibrillarin, and nucleolin, coordinating rRNA transcription and processing. It also functions in nucleolar stress responses, where its relocalization signals cellular stress or DNA damage. By applying NOLC1 antibody, scientists can study how nucleolar function integrates with signaling pathways in cancer, aging, and neurodegeneration.
NOLC1 mutations and expression changes contribute to oncogenesis. Overexpression correlates with tumor growth, while knockdown reduces proliferation. Because nucleolar size and activity are biomarkers of cancer, NOLC1 detection provides diagnostic and prognostic potential. NSJ Bioreagents offers NOLC1 antibody with validated specificity, ensuring reliable performance in nucleolar and cancer research. -
UniProt
- Q14978
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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