NFIB 抗体
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北京 101111
Quick Overview for NFIB 抗体 (ABIN7881837)
抗原
See all NFIB 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Nuclear factor 1 B-type Antibody / NFIB
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序列
- ELVRVS
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids ELVRVS RTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQR from the human protein were used as the immunogen for the Nuclear factor 1 B-type antibody.
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亚型
- IgG2b
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anti-Nuclear Factor I/B (NFIB) (AA 1-420) antibody
NFIB 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D6 unconjugated
anti-Nuclear Factor I/B (NFIB) antibodyNFIB 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor I/B (NFIB) antibodyNFIB 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor I/B (NFIB) (AA 1-420) antibodyNFIB 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Factor I/B (NFIB) antibodyNFIB 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB3600 unconjugated Recombinant Antibody
anti-Nuclear Factor I/B (NFIB) (AA 255-283) antibodyNFIB 适用: 人 WB 宿主: 兔 Polyclonal RB36790 unconjugated
anti-Nuclear Factor I/B (NFIB) (AA 1-233) antibodyNFIB 适用: 人 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor I/B (NFIB) (AA 187-236) antibodyNFIB 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 绵羊, Bat, 小鸡, Hamster, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor I/B (NFIB) antibodyNFIB 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Nuclear Factor I/B (NFIB) (AA 325-375) antibodyNFIB 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Nuclear factor 1 B-type antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Nuclear factor 1 B-type antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NFIB (Nuclear Factor I/B (NFIB))
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别名
- Nuclear factor 1 B-type
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背景
- Nuclear factor 1 B-type is a protein that in humans is encoded by the NFIB gene. The NFIB gene is a part of the NFI gene complex that includes three other genes (NFIA, NFIC and NFIX). The NFIB gene is a protein coding gene that also serves as a transcription factor. This gene is essential in embryonic development and it works together with its gene complex to initiate tissue differentiation in the fetus. Through knockout experiments, researchers found that mice without the NFIB gene have severely underdeveloped lungs. This mutation does not seem to cause spontaneous abortions because in utero the fetus does not use its lungs for respiration. However, this becomes lethal once the fetus is born and has to take its first breath. It is thought that NFIB plays a role in down regulating the transcription factors TGF-?1 and Shh in normal gestation because they remained high in knockout experiments. The absence of NFIB also leads to insufficient amounts of surfactant being produced which is one reason why the mice cannot breathe once it is born. The knockout experiments demonstrated that NFIB has a significant role in fore-brain development. NFIB is typically found in pontine nuclei of the CNS, the cerebral cortex and the white matter of the brain and without NFIB these areas are dramatically affected.
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UniProt
- O00712
抗原
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