Recombinant NrCAM 抗体
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Quick Overview for Recombinant NrCAM 抗体 (ABIN7881803)
抗原
See all NrCAM (NRCAM) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- NRCAM Antibody / Neuronal cell adhesion molecule
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to Neuronal cell adhesion molecule protein was used as the immunogen for the NRCAM antibody.
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亚型
- IgG
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anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 1192-1255) antibody
NRCAM 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7D8C5 unconjugated
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 390)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 390
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 488)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 488
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (PE)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 PE
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (PerCP)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 PerCP
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (HRP)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 HRP
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (APC)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 APC
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Biotin)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Biotin
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 594)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 594
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (FITC)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 FITC
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应用备注
- Optimal dilution of the NRCAM antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the NRCAM antibody at -20oC.
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- NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))
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别名
- NRCAM
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背景
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NRCAM antibody is a valuable reagent for studying neural development, cell adhesion, and axonal guidance. The encoded protein, neuronal cell adhesion molecule (NRCAM), is a member of the immunoglobulin superfamily of cell adhesion molecules. NRCAM is primarily expressed in the nervous system, where it mediates interactions between neurons and glial cells. By promoting cell-cell adhesion, axon pathfinding, and synapse formation, NRCAM plays a fundamental role in establishing and maintaining neural circuits.
During development, NRCAM contributes to neurite outgrowth and guidance by interacting with other adhesion molecules, extracellular matrix proteins, and cytoskeletal regulators. It facilitates the migration of neurons and the fasciculation of axons, ensuring proper connectivity in the developing brain and spinal cord. In mature neurons, NRCAM continues to support synaptic plasticity and neuronal communication, making it critical for both development and functional maintenance of the nervous system.
Research has linked NRCAM to multiple human diseases. Genetic studies suggest associations with autism spectrum disorders, schizophrenia, and attention deficit hyperactivity disorder, where altered cell adhesion and synaptic signaling may contribute to pathogenesis. NRCAM expression has also been implicated in cancer biology, particularly in melanoma and neuroblastoma, where it may promote tumor cell adhesion, migration, and metastasis. These findings highlight NRCAM as a multifunctional protein relevant to both neuroscience and oncology.
At the molecular level, neuronal cell adhesion molecule contains six immunoglobulin-like domains and five fibronectin type III repeats, followed by a single transmembrane region and a cytoplasmic tail. This structure enables NRCAM to form homophilic and heterophilic interactions that regulate adhesion and signaling. Through links to the actin cytoskeleton and intracellular kinases, NRCAM modulates cellular morphology, motility, and signaling responses.
The NRCAM antibody is widely used in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to detect protein expression and localization. These applications are essential for mapping NRCAM distribution in developing and mature tissues, as well as examining its role in disease states. For researchers focused on neural connectivity, synapse biology, or tumor cell behavior, the NRCAM antibody provides a reliable detection tool. NSJ Bioreagents offers validated antibodies that deliver reproducibility and precision in advanced molecular studies. -
UniProt
- Q92823
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途径
- Regulation of Cell Size
抗原
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