MSTN 抗体
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Quick Overview for MSTN 抗体 (ABIN7881742)
抗原
See all MSTN 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- GDF8 Antibody / Myostatin
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序列
- SGECEFVFLQ KYPH
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纯化方法
- Affinity purified
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免疫原
- Amino acids SGECEFVFLQKYPH from the human protein were used as the immunogen for the GDF8 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the GDF8 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GDF8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MSTN (Myostatin (MSTN))
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别名
- GDF8
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背景
- Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.
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UniProt
- O14793
抗原
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