Recombinant MVP 抗体
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北京 101111
Quick Overview for Recombinant MVP 抗体 (ABIN7881541)
抗原
See all MVP 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant MVP Antibody / Major Vault Protein
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纯化方法
- Protein A/G affinity
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免疫原
- Proteins precipitated from human breast cancer MCF-7 cells were used as the immunogen for the recombinant MVP antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the recombinant MVP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant MVP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MVP (Major Vault Protein (MVP))
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别名
- MVP
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背景
- Recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70 % of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
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UniProt
- Q14764
抗原
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