L1CAM 抗体
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北京 101111
Quick Overview for L1CAM 抗体 (ABIN7881450)
抗原
See all L1CAM 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- L1CAM Antibody / NCAM-L1 / CD171
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纯化方法
- Protein A/G affinity
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免疫原
- Homogenous suspension of 16-week human fetal brain cells were used as the immunogen for the L1CAM antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the L1CAM antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the L1CAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- L1CAM (L1 Cell Adhesion Molecule (L1CAM))
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别名
- L1CAM
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背景
- Recognizes a cell surface protein of 220-240 kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius), 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs), and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.
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UniProt
- P32004
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途径
- Synaptic Membrane
抗原
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