Recombinant KLC3 抗体
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北京 101111
Quick Overview for Recombinant KLC3 抗体 (ABIN7881445)
抗原
See all KLC3 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- KLC3 Antibody / Kinesin light chain 3
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human KLC3 was used as the immunogen for the KLC3 antibody.
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亚型
- IgG
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anti-Kinesin Light Chain 3 (KLC3) antibody
KLC3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB3760 unconjugated Recombinant Antibody
anti-Kinesin Light Chain 3 (KLC3) (AA 245-274) antibodyKLC3 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB26888 unconjugated
anti-Kinesin Light Chain 3 (KLC3) (AA 341-390) antibodyKLC3 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Kinesin Light Chain 3 (KLC3) (AA 251-300) antibodyKLC3 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, Cow, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the KLC3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the KLC3 antibody at -20oC.
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- KLC3 (Kinesin Light Chain 3 (KLC3))
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别名
- KLC3
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背景
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KLC3 antibody detects kinesin light chain 3, a subunit of the kinesin-1 Molecular motor complex responsible for microtubule-based transport. KLC proteins function as adaptors, linking cargo vesicles and organelles to kinesin heavy chains for movement toward the plus-end of microtubules. KLC3 is primarily expressed in testis and has unique roles in spermatogenesis, where it regulates transport of mitochondria and other organelles during sperm tail development.
Research using KLC3 antibody has shown that loss or dysfunction of KLC3 impairs mitochondrial localization in sperm flagella, leading to defective motility and male infertility. In animal models, KLC3 knockout results in abnormal sperm morphology and reduced fertility, confirming its importance for reproductive biology. Beyond reproduction, kinesin light chains also participate in neuronal transport, suggesting that KLC3 may share overlapping functions with other KLC isoforms in cargo regulation.
Aberrant regulation of kinesin proteins, including KLC3, has been linked to neurodegenerative disease and cancer. Disruption of intracellular transport contributes to neuronal dysfunction in disorders such as Alzheimer's disease, while tumor cells often exploit vesicle trafficking for signaling and survival. Studying KLC3 expression therefore offers insight into both specialized reproductive roles and broader cell biological processes.
Antibodies against KLC3 are validated for applications such as western blot, immunohistochemistry, and immunofluorescence. These reagents allow researchers to examine protein expression patterns, subcellular localization, and cargo-binding dynamics. Clone-based antibodies ensure high specificity when distinguishing KLC3 from closely related family members such as KLC1 and KLC2.
NSJ Bioreagents provides this KLC3 antibody for research in reproduction, intracellular trafficking, and disease pathways linked to motor protein function. -
UniProt
- Q6P597
抗原
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