Recombinant KRT17 抗体
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北京 101111
Quick Overview for Recombinant KRT17 抗体 (ABIN7881374)
抗原
See all KRT17 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Recombinant Cytokeratin 17 Antibody / KRT17 (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment of the human protein was used as the immunogen for the recombinant Cytokeratin 17 antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the recombinant Cytokeratin 17 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant Cytokeratin 17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- KRT17 (Keratin 17 (KRT17))
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别名
- Cytokeratin 17
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背景
- Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands, such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.
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UniProt
- Q04695
抗原
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