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Recombinant KRT17 抗体

The 兔 单克隆 anti-KRT17 antibody (Clone KRT17-8320R) (ABIN7881374) specifically detects KRT17 in IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN7881374
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Quick Overview for Recombinant KRT17 抗体 (ABIN7881374)

抗原

See all KRT17 抗体
KRT17 (Keratin 17 (KRT17))

抗体类型

Recombinant Antibody

适用

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宿主

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克隆类型

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单克隆

标记

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This KRT17 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

KRT17-8320R
  • 原理

    Recombinant Cytokeratin 17 Antibody / KRT17 (azide and preservative free)

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant fragment of the human protein was used as the immunogen for the recombinant Cytokeratin 17 antibody.

    亚型

    IgG, kappa
  • 应用备注

    Optimal dilution of the recombinant Cytokeratin 17 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    -20 °C

    储存方法

    Aliquot the recombinant Cytokeratin 17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    KRT17 (Keratin 17 (KRT17))

    别名

    Cytokeratin 17

    背景

    Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands, such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

    UniProt

    Q04695
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