Recombinant CDH6 抗体
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北京 101111
Quick Overview for Recombinant CDH6 抗体 (ABIN7881340)
抗原
See all CDH6 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant K-Cadherin Antibody / Cadherin 6 / CDH6
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant human Cadherin 6 protein (CDH6) was used as the immunogen for the recombinant K-Cadherin antibody.
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亚型
- IgG, kappa
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anti-K-Cadherin (CDH6) (AA 281-380) antibody
CDH6 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人 ELISA, FACS, BLI, Func, SPR 宿主: Human Monoclonal HKT288 unconjugated Recombinant Antibody
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人, 大鼠 WB, IHC, IHC (fro), ICC 宿主: 小鼠 Monoclonal 2B6 unconjugated
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB5060 unconjugated Recombinant Antibody
anti-K-Cadherin (CDH6) (AA 513-612) antibodyCDH6 适用: 人 WB, RNAi 宿主: 小鼠 Monoclonal 2F2 unconjugated
anti-K-Cadherin (CDH6) (AA 1-250) antibodyCDH6 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-K-Cadherin (CDH6) antibodyCDH6 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-K-Cadherin (CDH6) (AA 153-424) antibodyCDH6 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-K-Cadherin (CDH6) (AA 665-695), (C-Term) antibodyCDH6 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the recombinant K-Cadherin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant K-Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CDH6 (K-Cadherin (CDH6))
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别名
- K-Cadherin
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背景
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K-Cadherin antibody targets Cadherin 6, a calcium-dependent cell-cell adhesion molecule encoded by the CDH6 gene and a member of the classical cadherin family. Cadherin 6, also commonly referred to as K-Cadherin, is a single-pass transmembrane glycoprotein predominantly localized to the plasma membrane at adherens junctions, where it mediates homophilic interactions between neighboring cells. CDH6 expression is especially prominent in renal tubular epithelium, select epithelial tissues, and the nervous system, consistent with its role in epithelial organization and tissue morphogenesis.
Functionally, Cadherin 6 contributes to stable epithelial cohesion by linking adjacent cells through calcium-dependent adhesion and coupling to the actin cytoskeleton via catenin complexes. A short functional summary is that CDH6 maintains tissue architecture and epithelial integrity by regulating cell-cell adhesion and polarity. Through these adhesive interactions, K-Cadherin influences epithelial differentiation, cellular migration, and spatial organization during development and tissue maintenance.
At the molecular level, Cadherin 6 contains multiple extracellular cadherin repeat domains responsible for calcium binding and adhesive specificity, a single transmembrane region, and a conserved cytoplasmic tail that interacts with beta-catenin and associated adaptor proteins. These structural features integrate extracellular adhesion with intracellular signaling pathways. K-Cadherin antibody reagents are therefore valuable tools for studying adherens junction biology, epithelial cell behavior, and changes in adhesion dynamics under physiological and pathological conditions. Clone CDH6/9300R is designed to recognize Cadherin 6 and supports consistent detection of CDH6 expression in research applications.
From a biological and disease relevance perspective, altered CDH6 expression has been reported in several cancers, including renal cell carcinoma, ovarian cancer, and thyroid carcinoma, where changes in Cadherin 6 levels may correlate with tumor progression and invasive potential. K-Cadherin is also of interest in developmental biology due to its regulated expression during organogenesis. Clone CDH6/9300R provides a reliable reagent for examining Cadherin 6 expression in studies of epithelial differentiation, cancer biology, and cell adhesion mechanisms.
Developmentally, CDH6 expression is tightly regulated and contributes to tissue-specific patterning and morphogenetic processes, particularly in kidney development. K-Cadherin antibodies from NSJ Bioreagents are supplied for research use to support investigations in epithelial biology, developmental studies, and translational cancer research. -
UniProt
- P55285
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途径
- Cell-Cell Junction Organization
抗原
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