Recombinant IQGAP2 抗体
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Quick Overview for Recombinant IQGAP2 抗体 (ABIN7881328)
抗原
See all IQGAP2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- IQGAP2 Antibody / IQ motif containing GTPase activating protein 2
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human IQGAP2 was used as the immunogen for the IQGAP2 antibody.
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亚型
- IgG
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anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 1329-1544) antibody
IQGAP2 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyIQGAP2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyKD Validated IQGAP2 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 23GB4020 unconjugated Recombinant Antibody
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 343-449) antibodyIQGAP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B10 unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyIQGAP2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 1330-1440) antibodyIQGAP2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyKD Validated IQGAP2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2015 unconjugated Recombinant Antibody
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyIQGAP2 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 1245-1395) antibodyIQGAP2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 1436-1463), (C-Term) antibodyIQGAP2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB38598 unconjugated
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应用备注
- Optimal dilution of the IQGAP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the IQGAP2 antibody at -20oC.
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- IQGAP2 (IQ Motif Containing GTPase Activating Protein 2 (IQGAP2))
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别名
- IQGAP2
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背景
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IQGAP2 antibody detects IQ motif containing GTPase activating protein 2, encoded by the IQGAP2 gene. IQGAP2 belongs to a family of scaffolding proteins that integrate cytoskeletal dynamics, cell adhesion, and intracellular signaling. Unlike classical GTPase activating proteins, IQGAPs stabilize the active GTP bound form of small GTPases such as Rac1 and Cdc42. Through its IQ motifs, calponin homology domain, and RasGAP related domain, IQGAP2 coordinates actin reorganization, cell polarity, and signaling cascades.
IQGAP2 antibody is widely used in cancer biology, hepatology, and cytoskeletal research. IQGAP2 is highly expressed in liver, stomach, and testis. It regulates actin dynamics and adherens junctions by interacting with beta catenin, E cadherin, and F actin. Altered expression of IQGAP2 has been linked to hepatocellular carcinoma and gastric cancer, where loss of IQGAP2 promotes tumorigenesis. By detecting IQGAP2, researchers can study its tumor suppressor functions and its role in epithelial tissue integrity.
Western blot assays with IQGAP2 antibody detect protein bands in hepatic and epithelial tissues. Immunohistochemistry highlights expression in liver lobules and gastric mucosa, while immunofluorescence reveals cytoplasmic localization at cell junctions and actin filaments. ELISA enables quantification of IQGAP2 expression across experimental samples.
IQGAP2 participates in multiple signaling pathways, including Wnt, MAPK, and PI3K AKT. Its ability to bind both actin and signaling proteins positions it as a key scaffold at the plasma membrane. In cancer, IQGAP2 expression is frequently downregulated, contrasting with IQGAP1, which is often upregulated. This differential regulation underscores the unique tumor suppressive properties of IQGAP2. By applying IQGAP2 antibody, scientists can investigate how cytoskeletal regulation intersects with cancer biology and metabolic homeostasis.
IQGAP2 also plays roles in immune signaling and reproduction. In immune cells, it modulates cytoskeletal dynamics during migration and activation. In testis, IQGAP2 expression suggests involvement in spermatogenesis and germ cell polarity. These diverse roles make IQGAP2 antibody a valuable reagent for broad research areas beyond oncology.
IQGAP2 antibody from NSJ Bioreagents provides dependable specificity for studying cytoskeletal scaffolding and tumor suppression. Its strong performance across techniques ensures accurate detection of IQGAP2 in multiple research contexts. -
UniProt
- Q13576
抗原
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