Recombinant IQGAP2 抗体
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Quick Overview for Recombinant IQGAP2 抗体 (ABIN7881327)
抗原
See all IQGAP2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- IQGAP2 Antibody / IQ motif containing GTPase activating protein 2
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human IQGAP2 was used as the immunogen for the IQGAP2 antibody.
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亚型
- IgG
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anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 1329-1544) antibody
IQGAP2 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyIQGAP2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyKD Validated IQGAP2 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 23GB4020 unconjugated Recombinant Antibody
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 343-449) antibodyIQGAP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B10 unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyIQGAP2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 1330-1440) antibodyIQGAP2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyKD Validated IQGAP2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2015 unconjugated Recombinant Antibody
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) antibodyIQGAP2 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 1245-1395) antibodyIQGAP2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) (AA 1436-1463), (C-Term) antibodyIQGAP2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB38598 unconjugated
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应用备注
- Optimal dilution of the IQGAP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the IQGAP2 antibody at -20oC.
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- IQGAP2 (IQ Motif Containing GTPase Activating Protein 2 (IQGAP2))
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别名
- IQGAP2
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背景
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IQGAP2 antibody detects IQ motif containing GTPase activating protein 2, encoded by the IQGAP2 gene. IQ motif containing GTPase activating protein 2 belongs to the IQGAP family of scaffolding proteins that interact with Rho family GTPases, actin filaments, and signaling molecules. It plays an important role in cytoskeletal organization, cell adhesion, and intracellular signaling. IQGAP2 antibody provides researchers with a means to study its contribution to cytoskeletal regulation, liver physiology, and cancer biology.
Unlike its homolog IQGAP1, which promotes oncogenic signaling, IQGAP2 functions primarily as a tumor suppressor. Research with IQGAP2 antibody has shown that loss of IQGAP2 expression is frequent in hepatocellular carcinoma and gastric cancer, where it contributes to uncontrolled proliferation and reduced cell adhesion. By interacting with Rho family GTPases, IQGAP2 regulates actin dynamics and stabilizes adherens junctions, helping maintain epithelial integrity. Loss of this regulation increases motility and invasion, linking IQGAP2 deficiency to metastatic progression.
IQGAP2 is also important in liver biology. Studies using IQGAP2 antibody have demonstrated that knockout mice develop spontaneous hepatocellular carcinoma, confirming its tumor suppressor role. In normal liver tissue, IQGAP2 interacts with beta catenin and other signaling molecules to regulate hepatocyte growth and polarity. Dysregulation of this protein contributes to abnormal signaling through pathways such as Wnt and PI3K AKT, reinforcing its significance in liver disease and cancer.
Beyond the liver, IQGAP2 contributes to immune regulation and cytoskeletal remodeling in other tissues. It has been implicated in platelet activation, immune synapse formation, and gastric mucosal stability. Research with IQGAP2 antibody continues to expand understanding of its roles in diverse systems. Importantly, reduced expression of IQGAP2 in tumors is associated with poor prognosis, making it a potential biomarker for patient stratification.
IQGAP2 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects expression in liver and epithelial cell lines, while immunohistochemistry highlights its localization at cell junctions in tissues. Immunofluorescence reveals its colocalization with actin and signaling molecules, providing insights into cytoskeletal regulation. These methods ensure that IQGAP2 antibody is valuable for both fundamental and translational research.
By providing validated IQGAP2 antibody reagents, NSJ Bioreagents supports research into tumor suppression, cytoskeletal regulation, and liver cancer. Detection of IQ motif containing GTPase activating protein 2 helps researchers explore how scaffold proteins integrate signaling and structural networks in health and disease. -
UniProt
- Q13576
抗原
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