Recombinant IL-26 抗体
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Quick Overview for Recombinant IL-26 抗体 (ABIN7881300)
抗原
See all IL-26 (IL26) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- IL26 Antibody / Interleukin 26
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human IL26 was used as the immunogen for the IL26 antibody.
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亚型
- IgG
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anti-Interleukin 26 (IL26) (AA 74-171) antibody
IL26 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Interleukin 26 (IL26) antibodyIL26 适用: 人 WB 宿主: 兔 Monoclonal 25GB4810 unconjugated Recombinant Antibody
anti-Interleukin 26 (IL26) (Internal Region) antibodyIL26 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 26 (IL26) (AA 88-115) antibodyIL26 适用: 人 WB 宿主: 兔 Polyclonal RB23033 unconjugated
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应用备注
- Optimal dilution of the IL26 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the IL26 antibody at -20oC.
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- IL-26 (IL26) (Interleukin 26 (IL26))
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别名
- IL26
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背景
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IL26 antibody detects interleukin 26, a cytokine belonging to the IL-10 family that regulates immune cell communication. IL26 is secreted by activated T cells and natural killer cells, exerting its effects through a receptor complex composed of IL20RA and IL10RB subunits. This cytokine signals via STAT pathways to stimulate production of proinflammatory mediators, particularly in epithelial and immune cell populations.
Research using IL26 antibody has shown that IL26 plays a role in antimicrobial defense and inflammation. IL26 can directly bind extracellular DNA released from damaged cells or pathogens, forming complexes that amplify innate immune responses. In addition, IL26 has antimicrobial properties, acting as a cationic protein capable of disrupting bacterial membranes. Its dual role as both a cytokine and antimicrobial factor distinguishes IL26 from many other immune regulators.
Aberrant expression of IL26 has been linked to chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Elevated IL26 contributes to tissue damage by enhancing neutrophil and macrophage activity, while also promoting Th17-mediated inflammation. Conversely, IL26 signaling may support protective immunity against bacterial and viral infections, suggesting context-dependent effects.
Antibodies against IL26 are validated for assays such as western blot, ELISA, immunohistochemistry, and flow cytometry. These reagents allow researchers to monitor cytokine levels in serum or tissues and to analyze IL26 production by immune subsets. In clinical research, IL26 detection supports biomarker studies investigating disease activity or therapeutic response. Clone-based IL26 antibodies provide specificity that is crucial when distinguishing among closely related IL-10 family cytokines.
NSJ Bioreagents supplies this IL26 antibody to facilitate studies in immunology, infection biology, and inflammatory disease research. -
UniProt
- Q9NPH9
抗原
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