IL2RG 抗体
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北京 101111
Quick Overview for IL2RG 抗体 (ABIN7881295)
抗原
See all IL2RG 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- IL2RG Antibody / IL2 Receptor gamma
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序列
- QLQKKEIHLY QTFVVQLQD
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纯化方法
- Affinity purified
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免疫原
- Amino acids QLQKKEIHLYQTFVVQLQD from the human protein were used as the immunogen for the IL2RG antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the IL2RG antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the IL2RG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
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别名
- IL2RG
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背景
- IL2RG (INTERLEUKIN 2 RECEPTOR, GAMMA),also known as Common gamma chain or CD132, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors:IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte(white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, The IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL2 receptor. Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and direct programs of cellular differentiation. The sharing of the gamma subunit by several receptors explains why humans and mice that lack IL2 entirely show milder symptoms than those with IL2RG deficiency.
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UniProt
- P31785
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途径
- JAK/STAT Signaling, Growth Factor Binding
抗原
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