Recombinant IL18BP 抗体
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北京 101111
Quick Overview for Recombinant IL18BP 抗体 (ABIN7881287)
抗原
See all IL18BP 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- IL18BP Antibody / IL18 binding protein
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human IL18 binding protein was used as the immunogen for the IL18BP antibody.
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亚型
- IgG
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anti-Interleukin 18 Binding Protein (IL18BP) (AA 29-193) antibody
IL18BP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 Binding Protein (IL18BP) (AA 31-194) antibodyIL18BP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 Binding Protein (IL18BP) (AA 91-194) antibodyIL18BP 适用: 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 Binding Protein (IL18BP) (AA 31-194) antibodyIL18BP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A9 unconjugated
anti-Interleukin 18 Binding Protein (IL18BP) (C-Term) antibodyIL18BP 适用: 人, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 Binding Protein (IL18BP) antibodyIL18BP 适用: 人, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 Binding Protein (IL18BP) (AA 31-194) antibodyIL18BP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 5-2# unconjugated
anti-Interleukin 18 Binding Protein (IL18BP) (AA 29-193) antibodyIL18BP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 Binding Protein (IL18BP) (AA 29-193) antibodyIL18BP 适用: 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 Binding Protein (IL18BP) (AA 31-183) antibodyIL18BP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the IL18BP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the IL18BP antibody at -20oC.
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- IL18BP (Interleukin 18 Binding Protein (IL18BP))
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别名
- IL18BP
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背景
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IL18BP antibody detects interleukin 18 binding protein, encoded by the IL18BP gene. This secreted glycoprotein functions as a natural inhibitor of interleukin 18, a proinflammatory cytokine. Alternate names include IL18BPa, IL18BPb, and IL18BPc, reflecting the multiple isoforms generated by alternative splicing. IL18BP neutralizes IL18 by binding with high affinity, preventing its interaction with the IL18 receptor and subsequent activation of NF kappa B and interferon gamma pathways.
IL18BP antibody is widely applied in immunology, inflammation research, and translational medicine. By detecting IL18BP, researchers can investigate how immune regulation balances inflammatory cytokine activity. Overexpression of IL18BP provides protection from excessive inflammation, while deficiency or altered expression contributes to autoimmune disorders and infectious disease susceptibility.
ELISA detects IL18BP in serum and culture supernatants, while western blotting identifies isoform expression. Immunohistochemistry maps IL18BP production in tissues undergoing immune activation. These methods make IL18BP antibody useful for evaluating cytokine regulation in health and disease.
IL18BP has therapeutic potential as a biologic agent. Recombinant IL18BP has been developed to treat inflammatory diseases such as adult onset Still disease and hemophagocytic lymphohistiocytosis. By applying IL18BP antibody, researchers can monitor therapeutic levels and investigate how modulation of IL18 signaling influences disease outcomes.
IL18BP antibody from NSJ Bioreagents delivers dependable specificity for analyzing interleukin 18 binding protein. Its reliable performance across assays ensures accurate detection of this immune regulator. -
UniProt
- O95998
抗原
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