Human Papilloma Virus 18 E6 (HPV-18 E6) 抗体
The 小鼠 单克隆 anti-Human Papilloma Virus 18 E6 antibody (Clone HPV18-1297) (ABIN7881130) specifically detects Human Papilloma Virus 18 E6 in IHC (p).
The antibody is reactive with Human Papillomavirus 18 (HPV-18) samples.
产品编号 ABIN7881130
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Human Papilloma Virus 18 E6 (HPV-18 E6) 抗体 (ABIN7881130)
抗原
Human Papilloma Virus 18 E6 (HPV-18 E6)
适用
Human Papillomavirus 18 (HPV-18)
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
克隆位点
HPV18-1297
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原理
- HPV18 E6 Antibody
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纯化方法
- Protein G affinity chromatography
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免疫原
- HPV18 E6-i²-galactosidase fusion protein was used as the immunogen for this HPV18 E6 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the HPV18 E6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the HPV18 E6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- Human Papilloma Virus 18 E6 (HPV-18 E6)
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别名
- HPV18 E6
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物质类
- Viral Protein
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背景
- Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
抗原
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