Recombinant HOMER1 抗体
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北京 101111
Quick Overview for Recombinant HOMER1 抗体 (ABIN7881118)
抗原
See all HOMER1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- HOMER1 Antibody / SYN47
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Homer1 was used as the immunogen for the HOMER1 antibody.
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亚型
- IgG
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anti-Homer Homolog 1 (HOMER1) (Center) antibody
HOMER1 适用: 人, 小鼠, 大鼠 WB, ICC, IP, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) antibodyKD Validated HOMER1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB6005 unconjugated Recombinant Antibody
anti-Homer Homolog 1 (HOMER1) antibodyHOMER1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 96-122), (N-Term) antibodyHOMER1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18229 unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 101-150) antibodyHOMER1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig, 猴, Bat, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal AT1F3 unconjugated
anti-Homer Homolog 1 (HOMER1) antibodyHOMER1 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal AT1F3 unconjugated
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应用备注
- Optimal dilution of the HOMER1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the HOMER1 antibody at -20oC.
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- HOMER1 (Homer Homolog 1 (HOMER1))
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别名
- HOMER1
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背景
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HOMER1 antibody detects Homer protein homolog 1, encoded by the HOMER1 gene. Homer protein homolog 1 is a postsynaptic density scaffolding protein that plays a central role in synaptic signaling, calcium homeostasis, and plasticity. HOMER1 antibody provides researchers with a highly specific reagent for investigating synapse biology, learning and memory, and neurological disease.
Homer protein homolog 1 binds to proline rich motifs in receptors and signaling proteins at the postsynaptic density. Research using HOMER1 antibody has demonstrated that it directly interacts with metabotropic glutamate receptors, inositol trisphosphate receptors, and Shank family proteins. These interactions assemble macromolecular signaling complexes that coordinate calcium dynamics and synaptic responses. Through these scaffolding functions, HOMER1 is essential for coupling surface receptors to intracellular calcium stores and signaling pathways.
Alternative splicing of the HOMER1 gene produces both constitutively expressed long forms and inducible short forms. Studies with HOMER1 antibody have revealed that the long isoforms provide structural stability, while the short isoform Homer1a is an immediate early gene product induced by neuronal activity. Homer1a functions as a dominant negative regulator that disrupts multimeric complexes, thereby promoting synaptic remodeling and plasticity. This dual regulation highlights the versatility of HOMER1 in controlling neuronal signaling.
Dysregulation of Homer protein homolog 1 has been associated with neurological and psychiatric disorders. Research using HOMER1 antibody has shown that altered expression contributes to conditions such as schizophrenia, autism spectrum disorders, and depression. Abnormal Homer1a induction has also been implicated in epilepsy models, where it disrupts synaptic signaling balance. These findings underscore the importance of HOMER1 in maintaining normal brain function.
In addition to neurological disorders, HOMER1 influences cardiovascular physiology. Studies with HOMER1 antibody have indicated that Homer protein homolog 1 participates in excitation contraction coupling in cardiomyocytes by regulating calcium signaling between the sarcoplasmic reticulum and plasma membrane. Dysregulation of HOMER1 in cardiac cells may contribute to arrhythmias and heart failure.
HOMER1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes isoform expression, immunohistochemistry demonstrates postsynaptic enrichment in brain tissue, and immunofluorescence highlights colocalization with synaptic markers. These applications make HOMER1 antibody valuable for research into synaptic physiology and pathology.
By supplying validated HOMER1 antibody reagents, NSJ Bioreagents supports research into synaptic plasticity, neurological disorders, and signaling networks. Detection of Homer protein homolog 1 provides insight into how synaptic scaffolding proteins regulate communication and disease. -
UniProt
- Q86YM7
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途径
- Skeletal Muscle Fiber Development
抗原
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