Recombinant GSTA4 抗体
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北京 101111
Quick Overview for Recombinant GSTA4 抗体 (ABIN7880894)
抗原
See all GSTA4 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- GSTA4 Antibody / Glutathione S-transferase alpha 4
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human GSTA4 was used as the immunogen for the GSTA4 antibody.
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亚型
- IgG
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anti-Glutathione S-Transferase alpha 4 (GSTA4) (AA 3-222) antibody
GSTA4 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Glutathione S-Transferase alpha 4 (GSTA4) (AA 2-222) antibodyGSTA4 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione S-Transferase alpha 4 (GSTA4) (AA 1-222) antibodyGSTA4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutathione S-Transferase alpha 4 (GSTA4) (AA 1-222) antibodyGSTA4 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Glutathione S-Transferase alpha 4 (GSTA4) (AA 1-222) antibodyGSTA4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Glutathione S-Transferase alpha 4 (GSTA4) (AA 62-90), (N-Term) antibodyGSTA4 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22990 unconjugated
anti-Glutathione S-Transferase alpha 4 (GSTA4) (AA 168-222) antibodyGSTA4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Glutathione S-Transferase alpha 4 (GSTA4) (N-Term) antibodyGSTA4 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutathione S-Transferase alpha 4 (GSTA4) (AA 93-222) antibodyGSTA4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutathione S-Transferase alpha 4 (GSTA4) (AA 1-222) antibodyGSTA4 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GSTA4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the GSTA4 antibody at -20oC.
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- GSTA4 (Glutathione S-Transferase alpha 4 (GSTA4))
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别名
- GSTA4
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背景
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GSTA4 antibody detects glutathione S-transferase alpha 4, an enzyme of the glutathione S-transferase (GST) family that catalyzes detoxification reactions. GSTA4 conjugates reduced glutathione to electrophilic compounds, facilitating their neutralization and removal. This enzyme shows strong activity against lipid peroxidation products such as 4-hydroxynonenal (4-HNE), protecting cells from oxidative stress damage.
Research using GSTA4 antibody has shown the enzyme's importance in maintaining cellular redox balance. GSTA4 is highly expressed in liver and kidney, where it contributes to detoxification of reactive aldehydes and xenobiotics. Deficiency or reduced activity of GSTA4 can increase susceptibility to oxidative stress, leading to tissue damage and metabolic imbalance. Conversely, elevated expression may provide protective effects against oxidative injury.
In disease contexts, GSTA4 has been linked to cancer, neurodegeneration, and cardiovascular disease. Cancer cells often reprogram GST expression to resist chemotherapy, and GSTA4 activity may contribute to drug resistance. In neurobiology, GSTA4's role in detoxifying lipid peroxidation products positions it as a protective factor against disorders involving oxidative stress, such as Alzheimer's and Parkinson's disease. Variations in GSTA4 expression have also been studied in diabetes and atherosclerosis.
Antibodies against GSTA4 are validated for western blot, immunohistochemistry, and immunofluorescence. These tools allow researchers to monitor enzyme expression, subcellular localization, and regulation under oxidative or toxic stress. Clone-based antibodies provide specificity to distinguish GSTA4 from other GST family members.
NSJ Bioreagents offers this GSTA4 antibody to support research in oxidative stress, detoxification, and disease biology. -
UniProt
- O15217
抗原
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