Recombinant GALT 抗体
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北京 101111
Quick Overview for Recombinant GALT 抗体 (ABIN7880846)
抗原
See all GALT 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- GALT Antibody / Galactose-1-phosphate uridylyltransferase
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human GALT was used as the immunogen for the GALT antibody.
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亚型
- IgG
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anti-Galactose-1-Phosphate Uridylyltransferase (GALT) (AA 1-379) antibody
GALT 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4C11 unconjugated
anti-Galactose-1-Phosphate Uridylyltransferase (GALT) (AA 1-379) antibodyGALT 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Galactose-1-Phosphate Uridylyltransferase (GALT) (AA 344-373), (C-Term) antibodyGALT 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20969 unconjugated
anti-Galactose-1-Phosphate Uridylyltransferase (GALT) (AA 1-379) antibodyGALT 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Galactose-1-Phosphate Uridylyltransferase (GALT) antibodyKD Validated GALT 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2435 unconjugated Recombinant Antibody
anti-Galactose-1-Phosphate Uridylyltransferase (GALT) (AA 1-380) antibodyGALT 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4C11 unconjugated
anti-Galactose-1-Phosphate Uridylyltransferase (GALT) (AA 1-379) antibodyGALT 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Galactose-1-Phosphate Uridylyltransferase (GALT) (AA 1-379) antibodyGALT 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Galactose-1-Phosphate Uridylyltransferase (GALT) antibodyGALT 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Galactose-1-Phosphate Uridylyltransferase (GALT) antibodyGALT 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 4C11 unconjugated
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应用备注
- Optimal dilution of the GALT antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the GALT antibody at -20oC.
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- GALT (Galactose-1-Phosphate Uridylyltransferase (GALT))
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别名
- GALT
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背景
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GALT antibody detects Galactose-1-phosphate uridylyltransferase, encoded by the GALT gene. This enzyme plays an essential role in the Leloir pathway of galactose metabolism, where it catalyzes the transfer of uridylyl groups between UDP glucose and galactose-1-phosphate to form UDP galactose and glucose-1-phosphate. This reaction is central to the proper metabolism of dietary galactose, and deficiency in GALT activity leads to classic galactosemia, an inherited metabolic disorder. GALT antibody allows researchers to study enzyme expression, localization, and regulation in both normal physiology and disease contexts.
Galactose-1-phosphate uridylyltransferase is widely expressed in liver, kidney, and other metabolically active tissues. Research using GALT antibody has revealed that enzyme activity is tightly regulated, as accumulation of galactose-1-phosphate is toxic to cells. In classic galactosemia, mutations in the GALT gene result in absent or reduced activity, causing life threatening complications in infants such as liver failure, sepsis, and developmental delays. Early detection and dietary management are crucial, but long term complications still occur, making GALT antibody valuable in research aimed at improving therapies and understanding pathophysiology.
Beyond metabolic disorders, GALT has been studied in cancer and broader metabolic regulation. Alterations in carbohydrate metabolism are a hallmark of tumor cells, and studies using GALT antibody have suggested that reduced GALT activity may influence cancer cell growth through altered glycosylation and signaling pathways. In addition, polymorphisms in the GALT gene have been examined in population studies for their potential links to reproductive outcomes and susceptibility to metabolic stress. These investigations underscore the enzyme's relevance beyond rare genetic disease.
GALT antibody is widely used in western blotting, immunohistochemistry, and enzymatic activity assays. Western blotting confirms protein levels in cell and tissue lysates, while immunohistochemistry highlights tissue specific distribution. Functional assays combined with GALT antibody detection assess enzymatic activity under different experimental conditions, providing a comprehensive view of GALT regulation. These approaches make GALT antibody a powerful tool for metabolic research, clinical investigation, and biomarker development.
By supplying validated GALT antibody reagents, NSJ Bioreagents supports research into carbohydrate metabolism, genetic disease, and cancer biology. Detecting Galactose-1-phosphate uridylyltransferase provides insight into one of the most fundamental metabolic pathways and its connections to human health and disease. -
UniProt
- P07902
抗原
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