Recombinant FRG1 抗体
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北京 101111
Quick Overview for Recombinant FRG1 抗体 (ABIN7880823)
抗原
See all FRG1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- FRG1 Antibody / FSHD region gene 1
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human FRG1 was used as the immunogen for the FRG1 antibody.
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亚型
- IgG
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anti-FSHD Region Gene 1 (FRG1) (AA 1-258) antibody
FRG1 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 4A5 unconjugated
anti-FSHD Region Gene 1 (FRG1) (AA 1-258) antibodyFRG1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-FSHD Region Gene 1 (FRG1) antibodyKD Validated FRG1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2440 unconjugated Recombinant Antibody
anti-FSHD Region Gene 1 (FRG1) (Internal Region) antibodyVerified FRG1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-FSHD Region Gene 1 (FRG1) (AA 1-258) antibodyFRG1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-FSHD Region Gene 1 (FRG1) (AA 88-137) antibodyFRG1 适用: 人, 小鼠, 大鼠, Cow, 犬, 山羊, 豚鼠, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-FSHD Region Gene 1 (FRG1) (AA 118-167) antibodyFRG1 适用: 人, 小鼠, 大鼠, Cow, 犬, 山羊, 豚鼠, 马, 兔, Pig, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-FSHD Region Gene 1 (FRG1) (Middle Region) antibodyFRG1 适用: 人, 小鼠, 大鼠, Cow, 犬, 山羊, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the FRG1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the FRG1 antibody at -20oC.
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- FRG1 (FSHD Region Gene 1 (FRG1))
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别名
- FRG1
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背景
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FRG1 antibody detects FSHD region gene 1 protein, encoded by the FRG1 gene. This protein is associated with RNA processing, pre-mRNA splicing, and actin cytoskeleton organization. FRG1 antibody provides researchers with a critical reagent for investigating muscular dystrophy, RNA metabolism, and nuclear architecture. Interest in FRG1 intensified because of its location within the genomic region associated with facioscapulohumeral muscular dystrophy (FSHD), a progressive muscle wasting disease.
FSHD region gene 1 protein is expressed in both nuclear and cytoplasmic compartments. In the nucleus, it associates with splicing machinery and contributes to RNA maturation. Research using FRG1 antibody has demonstrated that overexpression of FRG1 alters splicing of muscle-specific transcripts, contributing to muscle pathology. In the cytoplasm, FRG1 interacts with actin filaments, influencing cytoskeletal organization and cell motility. These dual roles highlight its broad impact on cellular function.
Overexpression of FRG1 has been shown to produce muscular dystrophy-like phenotypes in model organisms. Studies with FRG1 antibody have confirmed that excessive expression disrupts muscle development, leading to muscle weakness and degeneration. This evidence supports the hypothesis that misregulation of FRG1 contributes to FSHD pathology. Conversely, controlled levels of FRG1 appear necessary for normal muscle and vascular development, linking its regulation to tissue homeostasis.
Beyond muscular dystrophy, FRG1 has been implicated in angiogenesis and vascular biology. Research with FRG1 antibody has revealed that it influences endothelial cell migration and capillary formation. Dysregulation of FRG1 may therefore contribute to vascular defects in addition to muscle abnormalities. This broadens the biological significance of FSHD region gene 1 protein to multiple tissues and disease processes.
FRG1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting identifies both endogenous and overexpressed FRG1, immunohistochemistry localizes it in muscle tissue, and immunofluorescence shows colocalization with nuclear speckles and actin filaments. These applications make FRG1 antibody indispensable for muscular dystrophy research.
By supplying validated FRG1 antibody reagents, NSJ Bioreagents supports studies of RNA processing, muscle disease, and cytoskeletal organization. Detection of FSHD region gene 1 protein provides insight into how RNA and cytoskeletal regulation intersect in development and pathology. -
UniProt
- Q14331
抗原
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