Recombinant FAM50A 抗体
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北京 101111
Quick Overview for Recombinant FAM50A 抗体 (ABIN7880762)
抗原
See all FAM50A 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- FAM50A Antibody / Family with sequence similarity 50 member A
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human FAM50A was used as the immunogen for the FAM50A antibody.
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亚型
- IgG
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anti-Family with Sequence Similarity 50, Member A (FAM50A) (AA 1-88) antibody
FAM50A 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5F10 unconjugated
anti-Family with Sequence Similarity 50, Member A (FAM50A) antibodyFAM50A 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Family with Sequence Similarity 50, Member A (FAM50A) (AA 1-89) antibodyFAM50A 适用: 人, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5F10 unconjugated
anti-Family with Sequence Similarity 50, Member A (FAM50A) (AA 311-339), (C-Term) antibodyFAM50A 适用: 人 WB, IF 宿主: 兔 Polyclonal RB44471 unconjugated
anti-Family with Sequence Similarity 50, Member A (FAM50A) (AA 1-339) antibodyFAM50A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Family with Sequence Similarity 50, Member A (FAM50A) antibodyKD Validated FAM50A 适用: 人 WB 宿主: 兔 Monoclonal 25GB6825 unconjugated Recombinant Antibody
anti-Family with Sequence Similarity 50, Member A (FAM50A) (AA 1-339) antibodyFAM50A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Family with Sequence Similarity 50, Member A (FAM50A) (C-Term) antibodyFAM50A 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 斑马鱼, Bat, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Family with Sequence Similarity 50, Member A (FAM50A) antibodyFAM50A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the FAM50A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the FAM50A antibody at -20oC.
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- FAM50A (Family with Sequence Similarity 50, Member A (FAM50A))
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别名
- FAM50A
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背景
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FAM50A antibody detects family with sequence similarity 50 member A, a nuclear protein involved in RNA processing and gene expression regulation. FAM50A is ubiquitously expressed and localized primarily to the nucleoplasm, where it associates with spliceosomal components and contributes to pre-mRNA splicing. Though relatively understudied compared to other RNA-binding proteins, evidence suggests FAM50A plays an important role in transcriptional control and cellular homeostasis.
Research using FAM50A antibody has linked the protein to development and disease. Genetic studies reveal that mutations in FAM50A cause Armfield X-linked intellectual disability syndrome, characterized by developmental delay, dysmorphic features, and neurobehavioral abnormalities. The disorder underscores FAM50A's significance in neurodevelopment and proper RNA processing. Knockout models further demonstrate embryonic lethality or severe neurological phenotypes, confirming its essential role.
Beyond development, FAM50A has been implicated in cancer biology. Altered expression is observed in several tumor types, where it may influence splicing decisions and transcriptional programs that favor proliferation. Transcriptome studies suggest that dysregulation of FAM50A perturbs global RNA processing networks, contributing to oncogenic transformation.
At the molecular level, FAM50A interacts with spliceosome-associated proteins, ribonucleoprotein complexes, and chromatin regulators. These interactions suggest a broader role in coupling transcription to RNA maturation. Additional evidence connects FAM50A to cell cycle control, where depletion disrupts proliferation and induces apoptosis.
Antibodies against FAM50A are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents enable detection of FAM50A in tissue and cell culture, supporting research into RNA biology, neurodevelopment, and tumorigenesis. Clone-based antibodies ensure reproducibility and specificity across experimental conditions.
NSJ Bioreagents offers this FAM50A antibody for research into RNA processing, gene regulation, and disease. -
UniProt
- Q14320
抗原
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