Recombinant EIF3A 抗体
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Quick Overview for Recombinant EIF3A 抗体 (ABIN7880749)
抗原
See all EIF3A 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- EIF3A Antibody / Eukaryotic translation initiation factor 3 subunit A
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human eIF3A was used as the immunogen for the EIF3A antibody.
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亚型
- IgG
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anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) (AA 13-477) antibody
EIF3A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) (AA 622-848) antibodyEIF3A 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) (AA 860-910) antibodyEIF3A 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) (AA 1-75) antibodyEIF3A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) (AA 1-75) antibodyEIF3A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G4 unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) (C-Term) antibodyEIF3A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) (AA 860-910) antibodyEIF3A 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) (AA 1288-1379) antibodyEIF3A 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) antibodyEIF3A 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB830 unconjugated Recombinant Antibody
anti-Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A) (AA 1219-1247), (C-Term) antibodyEIF3A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32052 unconjugated
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应用备注
- Optimal dilution of the EIF3A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the EIF3A antibody at -20oC.
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- EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))
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别名
- EIF3A
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背景
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EIF3A antibody detects eukaryotic translation initiation factor 3 subunit A, the largest subunit of the EIF3 complex. EIF3A is a central scaffold protein that coordinates the assembly of other EIF3 subunits, promoting formation of the 43S preinitiation complex. This step is essential for recruiting mRNA and initiating protein synthesis. EIF3A contributes to translation of specific mRNAs involved in cell cycle progression, signaling, and stress adaptation.
Research using EIF3A antibody has highlighted the protein's role in both normal cellular growth and cancer biology. EIF3A is frequently overexpressed in tumors, where it selectively enhances translation of oncogenes and suppresses translation of tumor suppressors. This imbalance contributes to tumor proliferation, survival, and metastasis. Studies have linked EIF3A to lung cancer, breast cancer, and hepatocellular carcinoma, making it a valuable biomarker and potential therapeutic target.
Beyond cancer, EIF3A is essential for embryonic development and cellular stress responses. Its regulation ensures that cells adapt translation rates during nutrient deprivation, hypoxia, or DNA damage. EIF3A dysfunction disrupts protein homeostasis, leading to impaired cell survival or uncontrolled growth. Because of this, EIF3A has become an important research focus in studies of translation control and disease mechanisms.
Antibodies against EIF3A are validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation. These reagents enable researchers to monitor EIF3A protein levels, examine subcellular localization, and analyze interactions within the EIF3 complex. Clone-based versions provide specificity required to distinguish EIF3A from other EIF3 subunits.
NSJ Bioreagents supplies this EIF3A antibody to support research in translation initiation, cancer pathways, and developmental biology. -
UniProt
- Q14152
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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