ERG 抗体
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北京 101111
Quick Overview for ERG 抗体 (ABIN7880736)
抗原
See all ERG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ERG Antibody / Transcriptional regulator ERG
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human ERG / Transcriptional regulator ERG was used as the immunogen for the ERG antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the ERG antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the ERG antibody at -20oC.
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- ERG (ERG, ETS transcription factor (ERG))
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别名
- ERG
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背景
- The ERG gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [RefSeq]
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UniProt
- P11308
抗原
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