Recombinant DBH 抗体
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北京 101111
Quick Overview for Recombinant DBH 抗体 (ABIN7880642)
抗原
See all DBH 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- DBH Antibody / Dopamine beta Hydroxylase
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Dopamine beta Hydroxylase was used as the immunogen for the DBH antibody.
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亚型
- IgG
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anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (AA 27-56) antibody
DBH 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (AA 34-64), (N-Term) antibodyDBH 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (AA 335-571) antibodyDBH 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (AA 27-56), (N-Term) antibodyDBH 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal RB19267 unconjugated
anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (AA 437-448) antibodyVerified DBH 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (Internal Region) antibodyDBH 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (N-Term) antibodyDBH 适用: 人, 灵长类 WB, IHC, IHC (p) 宿主: 绵羊 Polyclonal unconjugated
anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (C-Term) antibodyDBH 适用: 人, 小鼠, 灵长类 WB, IHC, IHC (p) 宿主: 绵羊 Polyclonal unconjugated
anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (AA 150-250) antibodyDBH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH) (AA 270-303) antibodyDBH 适用: 人 WB 宿主: 兔 Polyclonal RB48156 unconjugated
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应用备注
- Optimal dilution of the DBH antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the DBH antibody at -20oC.
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- DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))
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别名
- DBH
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背景
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DBH antibody detects dopamine beta hydroxylase, a copper-containing monooxygenase that catalyzes the conversion of dopamine to norepinephrine. This enzyme is expressed in the adrenal medulla and sympathetic neurons, where it plays a central role in catecholamine biosynthesis. DBH is localized within secretory vesicles, releasing norepinephrine into synaptic clefts and the circulatory system in response to stress and neuronal activation.
Research using DBH antibody has provided insight into neurobiology and disease. Alterations in DBH expression or activity can affect sympathetic nervous system function, influencing blood pressure regulation, stress responses, and mood. Low DBH activity has been associated with hypotension and autonomic dysfunction, while elevated activity contributes to hypertension. Genetic polymorphisms in DBH have been studied in relation to psychiatric disorders including schizophrenia, depression, and addiction.
DBH is also a marker of noradrenergic neurons and is used in neuroscience to study neuronal populations. In adrenal studies, DBH expression reflects catecholamine production capacity. Its role in neurotransmitter regulation makes it a therapeutic target in cardiovascular and psychiatric research. Additionally, DBH autoantibodies have been identified in certain autoimmune conditions, linking it to neuroimmune mechanisms.
Antibodies against DBH are validated for immunohistochemistry, immunofluorescence, ELISA, and western blot. These reagents allow detection of DBH in tissue sections, cell culture, and biological fluids. Clone-based DBH antibodies ensure reliable specificity for norepinephrine-related research.
NSJ Bioreagents supplies this DBH antibody for research into catecholamine biosynthesis, neurobiology, and disease. -
UniProt
- P09172
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途径
- Carbohydrate Homeostasis
抗原
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