DOK7 抗体
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北京 101111
Quick Overview for DOK7 抗体 (ABIN7880641)
抗原
See all DOK7 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- DOK7 Antibody / Docking protein 7
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序列
- STVEERVAQE ALETLQLEKR LSLLSHAGR
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids STVEERVAQEALETLQLEKRLSLLSHAGR from the human protein were used as the immunogen for the DOK7 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the DOK7 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the DOK7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- DOK7 (Docking Protein 7 (DOK7))
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别名
- DOK7
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背景
- Dok-7 is a non-catalytic cytoplasmic adaptor protein that is expressed specifically in muscle and is essential for the formation of neuromuscular synapses. Further, Dok-7 contains pleckstrin homology (PH) and phosphotyrosine-binding (PTB) domains that are critical for Dok-7 function. It is mapped to 4p16.3. The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
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UniProt
- Q18PE1
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途径
- Skeletal Muscle Fiber Development
抗原
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