Recombinant LAP3 抗体
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北京 101111
Quick Overview for Recombinant LAP3 抗体 (ABIN7880593)
抗原
See all LAP3 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- LAP3 Antibody / Leucine aminopeptidase 3
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human LAP3 was used as the immunogen for the LAP3 antibody.
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亚型
- IgG
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anti-Cytosol Aminopeptidase (LAP3) antibody
KD Validated LAP3 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 24GB5965 unconjugated Recombinant Antibody
anti-Cytosol Aminopeptidase (LAP3) (AA 420-519) antibodyLAP3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cytosol Aminopeptidase (LAP3) (AA 89-119), (N-Term) antibodyLAP3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14573 unconjugated
anti-Cytosol Aminopeptidase (LAP3) (AA 420-519) antibodyLAP3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G10 unconjugated
anti-Cytosol Aminopeptidase (LAP3) (AA 1-519) antibodyLAP3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cytosol Aminopeptidase (LAP3) (AA 1-519) antibodyLAP3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Cytosol Aminopeptidase (LAP3) (N-Term) antibodyLAP3 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Cytosol Aminopeptidase (LAP3) (N-Term) antibodyLAP3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytosol Aminopeptidase (LAP3) (AA 469-519) antibodyLAP3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytosol Aminopeptidase (LAP3) (AA 260-519) antibodyLAP3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the LAP3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the LAP3 antibody at -20oC.
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- LAP3 (Cytosol Aminopeptidase (LAP3))
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别名
- LAP3
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背景
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LAP3 antibody detects leucine aminopeptidase 3, a cytosolic enzyme that catalyzes the removal of N-terminal amino acids, particularly leucine, from peptides. LAP3 is involved in protein degradation, antigen processing, and amino acid recycling. Its activity contributes to maintaining intracellular amino acid pools and supporting protein turnover under normal and stress conditions.
Research using LAP3 antibody has linked this enzyme to cancer, autoimmune disease, and metabolic regulation. Elevated LAP3 expression has been reported in various cancers, including hepatocellular carcinoma and breast cancer, where it may promote tumor cell proliferation and invasion. LAP3 has also been implicated in antigen processing for MHC class I presentation, connecting it to immune system regulation. Genetic studies suggest associations between LAP3 variants and autoimmune conditions such as systemic lupus erythematosus.
In metabolic contexts, LAP3 participates in amino acid homeostasis and cellular responses to nutrient availability. Dysregulation of aminopeptidases can disrupt nitrogen balance and protein catabolism, influencing cell growth and survival. The dual role of LAP3 in both metabolism and immune regulation makes it an important target for research into cellular adaptation and disease mechanisms.
Antibodies against LAP3 are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents allow researchers to assess LAP3 expression in tissues, examine subcellular localization, and evaluate its contribution to immune and metabolic pathways. Clone-based LAP3 antibodies ensure specificity when distinguishing LAP3 from other aminopeptidase family members.
NSJ Bioreagents provides this LAP3 antibody for research into cancer biology, immunity, and metabolism. -
UniProt
- P28838
抗原
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