Recombinant CDK16 抗体
Our Local Distributor
北京 101111
Quick Overview for Recombinant CDK16 抗体 (ABIN7880535)
抗原
See all CDK16 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- CDK16 Antibody / PCTK1 / PCTAIRE1
-
纯化方法
- Affinity-chromatography
-
免疫原
- A synthesized peptide derived from human PCTAIRE1 was used as the immunogen for the CDK16 antibody.
-
亚型
- IgG
-
-
anti-Cyclin-Dependent Kinase 16 (CDK16) (AA 1-80) antibody
CDK16 适用: 人 WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 2E5 unconjugated
anti-Cyclin-Dependent Kinase 16 (CDK16) antibodyKD Validated CDK16 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB1495 unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase 16 (CDK16) (AA 1-80) antibodyCDK16 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4D2 unconjugated
anti-Cyclin-Dependent Kinase 16 (CDK16) (AA 1-496) antibodyCDK16 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 16 (CDK16) (AA 277-496) antibodyCDK16 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 16 (CDK16) (AA 357-386), (N-Term) antibodyCDK16 适用: 人 WB 宿主: 兔 Polyclonal RB8583 unconjugated
anti-Cyclin-Dependent Kinase 16 (CDK16) (AA 357-386) antibodyCDK16 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 16 (CDK16) (AA 1-496) antibodyCDK16 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 16 (CDK16) (N-Term) antibodyCDK16 适用: 人, 小鼠, 大鼠, Cow, 犬, 斑马鱼, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 16 (CDK16) (AA 277-496) antibodyCDK16 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the CDK16 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store the CDK16 antibody at -20oC.
-
-
- CDK16 (Cyclin-Dependent Kinase 16 (CDK16))
-
别名
- CDK16
-
背景
-
CDK16 antibody recognizes cyclin dependent kinase 16, also called PCTK1, PCTAIRE1, a member of the cyclin dependent kinase family encoded by the CDK16 gene. Unlike classical CDKs that regulate cell cycle checkpoints, CDK16 plays roles in vesicle trafficking, neuronal signaling, and spermatogenesis. It contains a conserved kinase domain and unique regulatory regions that interact with cyclins and adaptor proteins. CDK16 is highly expressed in brain and testis, consistent with its specialized functions in neurotransmission and reproduction.
CDK16 antibody is widely used in neuroscience and reproductive biology research. In neurons, CDK16 regulates exocytosis of synaptic vesicles, contributing to neurotransmitter release and synaptic plasticity. In germ cells, CDK16 supports spermatogenesis by modulating vesicular transport and cytoskeletal organization. Mutations or altered expression of CDK16 have been linked to intellectual disability, developmental delay, and reproductive disorders. By detecting CDK16, researchers can study how kinase signaling influences both neuronal communication and fertility.
The antibody is validated for western blotting, immunohistochemistry, immunofluorescence, and ELISA. In western blot assays, CDK16 antibody detects bands corresponding to expected isoforms, enabling quantitative comparisons across tissues. Immunohistochemistry demonstrates tissue localization in brain and testis, while immunofluorescence highlights cytoplasmic distribution in neurons and germ cells. ELISA applications allow measurement of CDK16 protein levels in experimental samples.
Beyond physiology, CDK16 has been implicated in cancer. Elevated expression has been reported in breast, lung, and prostate carcinoma, where it contributes to proliferation, survival, and invasion. CDK16 modulates signaling pathways that intersect with tumor suppressor networks, suggesting its role as a driver of oncogenesis. By applying CDK16 antibody, scientists can evaluate how kinase dysregulation promotes tumor development and whether CDK16 serves as a therapeutic target or biomarker.
CDK16 also participates in insulin secretion, immune responses, and cellular differentiation. Its broad influence highlights the importance of studying this kinase in diverse biological contexts. In experimental systems, CDK16 interacts with proteins that regulate exocytosis and endocytosis, linking it to fundamental processes of intracellular trafficking. This versatility makes CDK16 antibody a valuable reagent for both basic and translational research.
CDK16 antibody offered by NSJ Bioreagents delivers dependable specificity across platforms, supporting research into neuronal signaling, reproduction, cancer, and cellular communication. Its proven reliability ensures accurate detection of CDK16 in tissues and cell models, making it an essential tool for laboratories investigating kinase biology. -
UniProt
- Q00536
-
途径
- Hormone Transport
抗原
-
