Cyclin T1 抗体
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Quick Overview for Cyclin T1 抗体 (ABIN7880530)
抗原
See all Cyclin T1 (CCNT1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CCNT1 Antibody / Cyclin-T1
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序列
- QKQNSKSVPS AKVSLKEYRA KHAEELQKRQ LENM
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids QKQNSKSVPSAKVSLKEYRAKHAEELQKRQLENM from the human protein were used as the immunogen for the CCNT1 antibody.
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亚型
- IgG2b
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应用备注
- Optimal dilution of the CCNT1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the CCNT1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Cyclin T1 (CCNT1)
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别名
- CCNT1
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背景
- Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene. This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.
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UniProt
- O60563
抗原
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