Recombinant Cyclin H 抗体
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Quick Overview for Recombinant Cyclin H 抗体 (ABIN7880529)
抗原
See all Cyclin H (CCNH) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CCNH Antibody / Cyclin H
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纯化方法
- Affinity chromatography
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免疫原
- A synthetic peptide derived from human Cyclin H/p34 was used as the immunogen for the CCNH antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the CCNH antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the CCNH antibody at -20oC.
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- Cyclin H (CCNH)
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别名
- CCNH
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背景
- Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. [UniProt]
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UniProt
- P51946
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途径
- Cell Division Cycle, Mitotic G1-G1/S Phases, M Phase
抗原
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