Recombinant AER61 抗体
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北京 101111
Quick Overview for Recombinant AER61 抗体 (ABIN7880438)
抗原
See all AER61 (C3orf64) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- AER61 Antibody / EOGT
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human AER61 was used as the immunogen for the EOGT antibody.
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亚型
- IgG
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anti-Chromosome 3 Open Reading Frame 64 (C3orf64) antibody
KD Validated C3orf64 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3585 unconjugated Recombinant Antibody
anti-Chromosome 3 Open Reading Frame 64 (C3orf64) antibodyC3orf64 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 3 Open Reading Frame 64 (C3orf64) (C-Term) antibodyC3orf64 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 3 Open Reading Frame 64 (C3orf64) (AA 1-443) antibodyC3orf64 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chromosome 3 Open Reading Frame 64 (C3orf64) (C-Term) antibodyC3orf64 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 小鸡, Bat, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the EOGT antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the EOGT antibody at -20oC.
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- AER61 (C3orf64) (Chromosome 3 Open Reading Frame 64 (C3orf64))
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别名
- AER61
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背景
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EOGT antibody detects EGF domain specific O linked N acetylglucosamine transferase, an enzyme encoded by the EOGT gene. EOGT catalyzes the addition of O GlcNAc moieties to EGF like domains of secreted and membrane proteins, modifying signaling molecules and receptors. This post translational modification regulates ligand receptor interactions and signaling pathways critical for development and homeostasis.
EOGT antibody is widely used in studies of glycosylation, signaling, and developmental biology. By detecting EOGT, researchers can explore how O GlcNAc modification influences Notch signaling, growth factor binding, and tissue morphogenesis. Mutations in EOGT are associated with Adams Oliver syndrome, a developmental disorder characterized by limb and scalp defects, underscoring its biological importance.
In western blot assays, EOGT antibody detects protein bands corresponding to the enzyme in tissue and cell extracts. Immunohistochemistry maps expression in developing tissues, while immunofluorescence reveals subcellular localization consistent with endoplasmic reticulum and Golgi compartments. These methods support detailed analysis of glycosyltransferase biology.
EOGT mediated O GlcNAc modification contributes to signaling regulation in vascular and neural development. Dysregulation of this pathway has implications in congenital disorders, cancer, and immune regulation. By applying EOGT antibody, scientists can investigate how defects in protein glycosylation contribute to human disease and identify therapeutic strategies that target glycosylation pathways.
EOGT antibody from NSJ Bioreagents provides strong specificity for studying glycosylation and developmental biology. Its performance across multiple assays makes it a valuable reagent for exploring the role of O GlcNAc transferases in health and disease. -
UniProt
- Q5NDL2
抗原
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