C16ORF13 抗体
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北京 101111
Quick Overview for C16ORF13 抗体 (ABIN7880436)
抗原
See all C16ORF13 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- METTL26 Antibody / Methyltransferase-like protein 26
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human METTL26 recombinant protein (Position: A6- N204) was used as the immunogen for the METTL26 antibody.
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亚型
- IgG
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anti-Chromosome 16 Open Reading Frame 13 (C16ORF13) (AA 1-30), (N-Term) antibody
C16ORF13 适用: 人, Hamster WB, IHC (p) 宿主: 兔 Polyclonal RB25754 unconjugated
anti-Chromosome 16 Open Reading Frame 13 (C16ORF13) (AA 50-99) antibodyC16ORF13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 16 Open Reading Frame 13 (C16ORF13) (AA 1-30), (N-Term) antibodyC16ORF13 适用: 人, Hamster WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the METTL26 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the METTL26 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- C16ORF13 (Chromosome 16 Open Reading Frame 13 (C16ORF13))
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别名
- METTL26
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背景
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METTL26 antibody detects Methyltransferase-like protein 26, encoded by the METTL26 gene on chromosome 16p13.3. METTL26 antibody is used to investigate this putative methyltransferase that belongs to the large METTL family of proteins. Although its biochemical activity is less defined compared to other METTL members, METTL26 is thought to participate in RNA modification, epigenetic regulation, and potentially protein methylation. Expression has been reported in many tissues, with enrichment in brain and reproductive tissues, suggesting specialized roles in gene regulation and development.
Structurally, METTL26 contains an S-adenosylmethionine (SAM)-binding domain characteristic of methyltransferases. This domain is predicted to catalyze methyl group transfer, though specific substrates remain unidentified. Comparative analyses suggest METTL26 may have diverged to acquire unique functions in RNA processing or chromatin regulation. The protein may act as a scaffold in ribonucleoprotein complexes, linking methylation activity to RNA stability and translation.
Functionally, METTL26 is implicated in gene expression regulation. RNA-seq data show METTL26 knockdown affects expression of genes involved in cell cycle and RNA metabolism. Although its enzymatic targets are unknown, METTL26 may contribute to post-transcriptional regulation through RNA modification. Some studies suggest potential roles in splicing and small RNA pathways. Researchers apply METTL26 antibody to investigate these emerging functions in RNA biology and epigenetics.
Clinically, METTL26 remains underexplored, but methyltransferase-like proteins are increasingly associated with cancer, neurological disease, and developmental disorders. Given its expression in brain and reproductive tissues, METTL26 may influence neuronal differentiation, gametogenesis, or embryonic development. Its genomic location on 16p13.3 also makes it a candidate for involvement in congenital syndromes with deletions in this region. NSJ Bioreagents provides METTL26 antibody as a high-quality reagent to support the growing field of methyltransferase biology.
Experimentally, METTL26 antibody is used in western blotting to detect the ~30 kDa protein, in immunohistochemistry to evaluate tissue distribution, and in immunofluorescence microscopy to study subcellular localization. Immunoprecipitation with METTL26 antibody may help identify binding partners and clarify its biological role. These studies will help establish its significance in RNA processing and epigenetic control. -
UniProt
- Q96S19
抗原
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