Recombinant Nesprin3 抗体
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北京 101111
Quick Overview for Recombinant Nesprin3 抗体 (ABIN7880434)
抗原
See all Nesprin3 (C14orf49) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Nesprin 3 Antibody / SYNE3
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Nesprin3 was used as the immunogen for the Nesprin 3 antibody.
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亚型
- IgG
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anti-Chromosome 14 Open Reading Frame 49 (C14orf49) (AA 322-495) antibody
C14orf49 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 14 Open Reading Frame 49 (C14orf49) (AA 740-920) antibodyC14orf49 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 14 Open Reading Frame 49 (C14orf49) antibodyKD Validated C14orf49 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4670 unconjugated Recombinant Antibody
anti-Chromosome 14 Open Reading Frame 49 (C14orf49) (AA 852-880), (C-Term) antibodyC14orf49 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB28457 unconjugated
anti-Chromosome 14 Open Reading Frame 49 (C14orf49) (N-Term) antibodyC14orf49 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 14 Open Reading Frame 49 (C14orf49) (Internal Region) antibodyC14orf49 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 14 Open Reading Frame 49 (C14orf49) (Internal Region) antibodyC14orf49 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 14 Open Reading Frame 49 (C14orf49) antibodyC14orf49 适用: 人 WB 宿主: 兔 Monoclonal 23GB4665 unconjugated Recombinant Antibody
anti-Chromosome 14 Open Reading Frame 49 (C14orf49) (AA 855-884), (C-Term) antibodyC14orf49 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 14 Open Reading Frame 49 (C14orf49) (Center) antibodyC14orf49 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Nesprin 3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Nesprin 3 antibody at -20oC.
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- Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))
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别名
- Nesprin 3
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背景
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Nesprin 3 antibody detects Spectrin repeat containing nuclear envelope protein 3, encoded by the SYNE3 gene. This protein, commonly known as Nesprin 3, is a component of the linker of nucleoskeleton and cytoskeleton (LINC) complex that spans the nuclear envelope. Unlike other Nesprin family members that link directly to actin, Nesprin 3 connects to intermediate filaments through interactions with plectin. Nesprin 3 antibody provides researchers with a key reagent to study nuclear positioning, mechanotransduction, and cytoskeletal organization.
The LINC complex plays a central role in transmitting mechanical forces between the cytoskeleton and the nucleus. By tethering the nuclear envelope to intermediate filament networks, Nesprin 3 contributes to nuclear anchorage during migration, differentiation, and mitosis. Research using Nesprin 3 antibody has shown that loss of this protein disrupts nuclear shape and mechanosensing, leading to altered transcriptional responses. These findings emphasize the importance of Nesprin 3 in structural integrity and gene regulation.
Dysfunction of Nesprin proteins, including Nesprin 3, has been linked to muscular dystrophies, cardiomyopathies, and neurological disorders. While most studies have focused on Nesprin 1 and Nesprin 2, evidence suggests that Nesprin 3 contributes to nuclear envelope stability and tissue homeostasis. Studies using Nesprin 3 antibody have associated its altered expression with cancer progression, where changes in nuclear deformability affect invasion and metastasis. These roles highlight the significance of SYNE3 in both health and disease.
Nesprin 3 antibody is widely applied in western blotting, immunofluorescence, and immunohistochemistry. Western blotting demonstrates isoform expression, immunofluorescence shows its localization at the nuclear envelope, and immunohistochemistry reveals its distribution in tissues such as muscle, epithelium, and nervous system. Functional studies have employed Nesprin 3 antibody in knockdown and rescue experiments, linking its absence to nuclear detachment and impaired motility.
By providing validated Nesprin 3 antibody reagents, NSJ Bioreagents supports research into nuclear envelope biology, cytoskeletal dynamics, and disease. Detection of Spectrin repeat containing nuclear envelope protein 3 ensures that researchers can explore how nuclear anchorage and mechanotransduction contribute to cellular function and pathology. -
UniProt
- Q6ZMZ3
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途径
- Maintenance of Protein Location
抗原
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