Recombinant Ceruloplasmin 抗体
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北京 101111
Quick Overview for Recombinant Ceruloplasmin 抗体 (ABIN7880387)
抗原
See all Ceruloplasmin (CP) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Ceruloplasmin Antibody / CP
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Ceruloplasmin was used as the immunogen for the Ceruloplasmin antibody.
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亚型
- IgG
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anti-Ceruloplasmin (Ferroxidase) (CP) (AA 789-1065) antibody
CP 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Ceruloplasmin (Ferroxidase) (CP) (AA 789-1065) antibodyCP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ceruloplasmin (Ferroxidase) (CP) (AA 20-258) antibodyCP 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ceruloplasmin (Ferroxidase) (CP) (AA 121-151), (N-Term) antibodyCP 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19057 unconjugated
anti-Ceruloplasmin (Ferroxidase) (CP) (AA 121-151) antibodyCP 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ceruloplasmin (Ferroxidase) (CP) (AA 547-577) antibodyCP 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ceruloplasmin (Ferroxidase) (CP) (AA 547-577), (Center) antibodyCP 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19058 unconjugated
anti-Ceruloplasmin (Ferroxidase) (CP) (AA 872-1059) antibodyCP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ceruloplasmin (Ferroxidase) (CP) (AA 20-259) antibodyCP 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ceruloplasmin (Ferroxidase) (CP) antibodyCP 适用: 人, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Ceruloplasmin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Ceruloplasmin antibody at -20oC.
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- Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))
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别名
- Ceruloplasmin
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背景
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Ceruloplasmin antibody detects ceruloplasmin, a copper binding glycoprotein encoded by the CP gene. Ceruloplasmin is synthesized in the liver and secreted into the plasma, where it carries more than 95 percent of circulating copper. It functions as a ferroxidase enzyme that oxidizes Fe2 plus to Fe3 plus, enabling iron binding to transferrin. Through this activity, ceruloplasmin maintains systemic iron and copper balance, supports antioxidant defense, and regulates oxidative stress.
Ceruloplasmin antibody is widely applied in studies of metabolism, neurodegeneration, and inflammatory disease. Abnormal ceruloplasmin levels are associated with Wilson disease, aceruloplasminemia, and other disorders of copper metabolism. In addition, altered expression occurs in Parkinson disease and Alzheimer disease, where oxidative stress contributes to pathogenesis. By detecting ceruloplasmin, researchers can evaluate copper homeostasis and its links to neurological disorders.
In western blot assays, ceruloplasmin antibody detects protein bands of the expected size in serum and liver extracts. Immunohistochemistry highlights hepatocyte production and distribution in tissues, while ELISA applications support quantification of ceruloplasmin levels in plasma. These methods make ceruloplasmin antibody useful for both clinical and experimental research.
Ceruloplasmin also acts as an acute phase reactant, with levels rising during inflammation and infection. Elevated ceruloplasmin is observed in autoimmune disease, cardiovascular disease, and cancer. By applying ceruloplasmin antibody, scientists can study how changes in CP expression reflect inflammation and metabolic stress.
Ceruloplasmin antibody from NSJ Bioreagents offers reliable specificity for studying copper and iron metabolism, oxidative stress, and disease mechanisms. Its performance across multiple assays makes it a valuable resource for metabolic and neurological research. -
UniProt
- P00450
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途径
- Transition Metal Ion Homeostasis
抗原
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