Recombinant CRABP2 抗体
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北京 101111
Quick Overview for Recombinant CRABP2 抗体 (ABIN7880384)
抗原
See all CRABP2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CRABP2 Antibody / Cellular retinoic acid-binding protein 2
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human CRABP2 was used as the immunogen for the CRABP2 antibody.
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亚型
- IgG
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anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) (AA 1-138) antibody
CRABP2 适用: 人 WB, IHC, ICC, FACS, IP 宿主: 兔 Polyclonal unconjugated
anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) antibodyCRABP2 适用: 人 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 10D6 unconjugated
anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) (AA 1-138) antibodyCRABP2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4F2 unconjugated
anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) antibodyKD Validated CRABP2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4790 unconjugated Recombinant Antibody
anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) antibodyCRABP2 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) (AA 75-125) antibodyCRABP2 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) (AA 1-138) antibodyCRABP2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) (C-Term) antibodyCRABP2 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) (AA 1-138) antibodyCRABP2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cellular Retinoic Acid Binding Protein 2 (CRABP2) (AA 22-94) antibodyCRABP2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CRABP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the CRABP2 antibody at -20oC.
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- CRABP2 (Cellular Retinoic Acid Binding Protein 2 (CRABP2))
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别名
- CRABP2
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背景
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CRABP2 antibody detects cellular retinoic acid-binding protein 2, encoded by the CRABP2 gene. Alternate names include CRABP-II, cellular retinoic acid-binding protein type II, and RA-binding protein 2. CRABP2 is a cytoplasmic protein that binds retinoic acid with high affinity, delivering it to the nucleus to interact with retinoic acid receptors (RARs). This shuttling mechanism ensures efficient retinoic acid signaling, which regulates cell differentiation, growth, and development. Structurally, CRABP2 belongs to the fatty acid-binding protein family, characterized by a beta-barrel fold that binds hydrophobic ligands.
CRABP2 antibody is widely applied in developmental biology, cancer research, and dermatology. Retinoic acid is essential for embryonic patterning, limb development, and organogenesis, and CRABP2 ensures delivery of ligand to nuclear receptors. In skin, CRABP2 regulates keratinocyte differentiation and retinoid responses, linking it to dermatological therapies. In cancer biology, CRABP2 expression modulates sensitivity to retinoids, influencing proliferation and apoptosis.
Applications of CRABP2 antibody include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blotting detects CRABP2 protein in cell and tissue lysates, immunohistochemistry maps expression in embryonic and tumor tissues, and immunofluorescence highlights cytoplasmic and nuclear localization. These methods support research into retinoid signaling in diverse contexts.
Dysregulation of CRABP2 is linked to developmental abnormalities, cancer progression, and skin disease. Overexpression promotes retinoid sensitivity in some cancers, while downregulation confers resistance. By applying CRABP2 antibody, researchers can study how retinoid signaling contributes to disease and therapy response.
CRABP2 interacts with nuclear RARs, cytoplasmic enzymes, and signaling molecules. This positions it as a central mediator of vitamin A biology. NSJ Bioreagents provides CRABP2 antibody with validated specificity, supporting accurate detection in studies of development, cancer, and dermatology. -
UniProt
- P29373
抗原
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