Cathepsin D 抗体
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Quick Overview for Cathepsin D 抗体 (ABIN7880202)
抗原
See all Cathepsin D (CTSD) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- CTSD Antibody / Cathepsin D (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Purified His-tagged CTSD protein was used as the immunogen for the CTSD antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the CTSD antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the CTSD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Cathepsin D (CTSD)
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别名
- CTSD
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背景
- Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimers disease.
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UniProt
- P07339
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途径
- Peptide Hormone Metabolism
抗原
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