Recombinant CBR1 抗体
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北京 101111
Quick Overview for Recombinant CBR1 抗体 (ABIN7880172)
抗原
See all CBR1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CBR1 Antibody / Carbonyl reductase 1
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human CBR1 was used as the immunogen for the CBR1 antibody.
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亚型
- IgG
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anti-Carbonyl Reductase 1 (CBR1) (C-Term) antibody
Verified CBR1 适用: 人 WB, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Carbonyl Reductase 1 (CBR1) (AA 14-262) antibodyCBR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Carbonyl Reductase 1 (CBR1) (AA 66-271) antibodyCBR1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Carbonyl Reductase 1 (CBR1) (AA 1-277) antibodyCBR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D12-1G8 unconjugated
anti-Carbonyl Reductase 1 (CBR1) (AA 1-277) antibodyCBR1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Carbonyl Reductase 1 (CBR1) (AA 1-277) antibodyCBR1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Carbonyl Reductase 1 (CBR1) antibodyKD Validated CBR1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB3655 unconjugated
anti-Carbonyl Reductase 1 (CBR1) antibodyCBR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Carbonyl Reductase 1 (CBR1) (Middle Region) antibodyCBR1 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔, 犬, 豚鼠, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carbonyl Reductase 1 (CBR1) (C-Term) antibodyCBR1 适用: 人, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CBR1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the CBR1 antibody at -20oC.
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- CBR1 (Carbonyl Reductase 1 (CBR1))
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别名
- CBR1
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背景
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CBR1 antibody detects Carbonyl reductase 1, encoded by the CBR1 gene. Carbonyl reductase 1 is an NADPH dependent enzyme that catalyzes the reduction of carbonyl containing compounds to their corresponding alcohols. This enzyme is part of the short chain dehydrogenase/reductase family and has a broad substrate spectrum, including xenobiotics, endogenous prostaglandins, and pharmacological agents. CBR1 antibody provides a valuable tool for studying drug metabolism, detoxification, and cellular defense mechanisms against reactive carbonyl species.
Carbonyl reductase 1 contributes to the metabolism of anthracycline drugs such as doxorubicin, converting them to less active alcohol metabolites. While this reduces anticancer activity, it also influences drug toxicity, particularly cardiotoxicity. Research with CBR1 antibody has been central to understanding interindividual variability in anthracycline metabolism and its impact on therapeutic outcomes. CBR1 also reduces prostaglandins and quinones, helping regulate inflammatory responses and oxidative stress signaling.
CBR1 has been linked to cancer, cardiovascular disease, and neurodegeneration. Overexpression has been reported in several tumors, where it may promote resistance to chemotherapy. Conversely, genetic polymorphisms in the CBR1 gene influence enzymatic activity and alter susceptibility to drug side effects. Using CBR1 antibody, researchers have demonstrated its tissue specific expression, with high levels in liver, kidney, and heart, reflecting its role in systemic detoxification. These findings underscore the enzyme's dual role in both protecting tissues and modulating pharmacological efficacy.
CBR1 antibody is applicable in western blotting, immunohistochemistry, and enzymatic activity assays. Western blotting demonstrates isoform expression across tissues, while immunohistochemistry reveals cytosolic distribution. Activity based assays combined with CBR1 antibody confirm enzyme function and response to inhibitors. These approaches allow detailed mapping of metabolic pathways influenced by Carbonyl reductase 1.
By providing validated CBR1 antibody reagents, NSJ Bioreagents supports research into drug metabolism, pharmacogenetics, and detoxification pathways. Detection of Carbonyl reductase 1 offers insights into how cellular defenses interact with therapeutic agents and environmental exposures. -
UniProt
- P16152
抗原
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