Recombinant Centaurin beta 2 抗体
Our Local Distributor
北京 101111
Quick Overview for Recombinant Centaurin beta 2 抗体 (ABIN7879997)
抗原
See all Centaurin beta 2 (ACAP2) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- ACAP2 Antibody / ArfGAP with coiled-coil ankyrin repeat and PH domains 2
-
纯化方法
- Affinity-chromatography
-
免疫原
- A synthesized peptide derived from human ACAP2 was used as the immunogen for the ACAP2 antibody.
-
亚型
- IgG
-
-
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) (AA 473-581) antibody
ACAP2 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 4G3 unconjugated
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) antibodyKD Validated ACAP2 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1565 unconjugated Recombinant Antibody
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) (C-Term) antibodyVerified ACAP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) (AA 350-400) antibodyACAP2 适用: 人, 小鼠, 大鼠, 犬, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) (AA 489-522) antibodyACAP2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51552 unconjugated
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) (AA 50-160) antibodyACAP2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) (AA 764-798), (C-Term) antibodyACAP2 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB51844 unconjugated
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) (AA 1-778) antibodyACAP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) (AA 728-778) antibodyACAP2 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2) antibodyKD Validated ACAP2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
-
-
应用备注
- Optimal dilution of the ACAP2 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store the ACAP2 antibody at -20oC.
-
-
- Centaurin beta 2 (ACAP2) (ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2))
-
别名
- ACAP2
-
背景
-
ACAP2 antibody detects ArfGAP with coiled-coil, ankyrin repeat, and PH domains 2, a GTPase-activating protein that regulates ADP-ribosylation factor 6 (ARF6). ACAP2 controls membrane trafficking and actin cytoskeleton remodeling by accelerating the hydrolysis of ARF6-bound GTP. Through these functions, ACAP2 coordinates processes such as endocytosis, recycling, and cell migration.
Research using ACAP2 antibody demonstrates its role in neuronal and immune cell biology. In neurons, ACAP2 regulates dendritic spine development and axon guidance by modulating actin remodeling. In immune cells, ACAP2 contributes to receptor trafficking and migration, influencing both innate and adaptive responses. Dysregulation of ACAP2 has been associated with impaired immune function and altered neuronal connectivity.
ACAP2 is also studied in cancer and viral infections. Tumor cells exploit ARF6 signaling pathways to promote invasion and metastasis, and ACAP2 acts as a regulator of this activity. Reduced ACAP2 expression can enhance ARF6-mediated oncogenic signaling. Viral pathogens, including some RNA viruses, utilize ARF6 and its regulators to facilitate replication and budding, suggesting ACAP2 may indirectly impact host-pathogen interactions.
Antibodies against ACAP2 are validated for western blot, immunofluorescence, and immunohistochemistry. These reagents allow researchers to investigate protein localization, expression levels, and interactions with ARF6 and related molecules. Clone-based antibodies provide specificity to ensure consistent results across experimental systems.
NSJ Bioreagents supplies this ACAP2 antibody for studies in membrane trafficking, cytoskeletal regulation, and signaling pathways. -
UniProt
- Q15057
抗原
-
