Fetuin A 抗体
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北京 101111
Quick Overview for Fetuin A 抗体 (ABIN7879956)
抗原
See all Fetuin A (AHSG) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Fetuin-A Antibody / AHSG
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant protein fragment was used as the immunogen for the Fetuin-A antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the Fetuin-A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Fetuin-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))
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别名
- Fetuin-A
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背景
- Fetuin (also designated 2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.
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UniProt
- P02765
抗原
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