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Fetuin A 抗体

The 小鼠 单克隆 anti-Fetuin A antibody is suitable to detect Fetuin A in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7879956
发货至: 中国
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Quick Overview for Fetuin A 抗体 (ABIN7879956)

抗原

See all Fetuin A (AHSG) 抗体
Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Fetuin A antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

AHSG-3748
  • 原理

    Fetuin-A Antibody / AHSG

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant protein fragment was used as the immunogen for the Fetuin-A antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the Fetuin-A antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the Fetuin-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))

    别名

    Fetuin-A

    背景

    Fetuin (also designated 2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.

    UniProt

    P02765
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