ALDH1L1 抗体
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北京 101111
Quick Overview for ALDH1L1 抗体 (ABIN7879932)
抗原
See all ALDH1L1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- 10-Formyltetrahydrofolate dehydrogenase Antibody / ALDH1L1
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment of human ALDH1L1 protein was used as the immunogen for the 10-Formyltetrahydrofolate dehydrogenase antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the 10-Formyltetrahydrofolate dehydrogenase antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the 10-Formyltetrahydrofolate dehydrogenase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- ALDH1L1 (Aldehyde Dehydrogenase 1 Family, Member L1 (ALDH1L1))
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别名
- 10-Formyltetrahydrofolate dehydrogenase
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背景
- Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1L1 (aldehyde dehydrogenase 1 family member L1), also known as FTHFD or 10-FTHFD (10-formyltetrahydrofolate dehydrogenase), is a cytosolic protein that is developmentally regulated in the cerebellum. ALDH1L1 binds to folate and catalyzes the conversion of 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF). This suggests a possible role for ALDH1L1 in the regulation of cellular THF levels as well as in the inhibition of cell proliferation (as 10-FTHF is essential for the synthesis of purine). In addition, the overexpression of ALDH1L1 can restrict cell proliferation in vitro.
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UniProt
- O75891
抗原
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