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ALDH1L1 抗体

The 小鼠 单克隆 anti-ALDH1L1 antibody is suitable to detect ALDH1L1 in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7879932
发货至: 中国
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Quick Overview for ALDH1L1 抗体 (ABIN7879932)

抗原

See all ALDH1L1 抗体
ALDH1L1 (Aldehyde Dehydrogenase 1 Family, Member L1 (ALDH1L1))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This ALDH1L1 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

ALDH1L1-7968
  • 原理

    10-Formyltetrahydrofolate dehydrogenase Antibody / ALDH1L1

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant fragment of human ALDH1L1 protein was used as the immunogen for the 10-Formyltetrahydrofolate dehydrogenase antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the 10-Formyltetrahydrofolate dehydrogenase antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the 10-Formyltetrahydrofolate dehydrogenase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    ALDH1L1 (Aldehyde Dehydrogenase 1 Family, Member L1 (ALDH1L1))

    别名

    10-Formyltetrahydrofolate dehydrogenase

    背景

    Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1L1 (aldehyde dehydrogenase 1 family member L1), also known as FTHFD or 10-FTHFD (10-formyltetrahydrofolate dehydrogenase), is a cytosolic protein that is developmentally regulated in the cerebellum. ALDH1L1 binds to folate and catalyzes the conversion of 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF). This suggests a possible role for ALDH1L1 in the regulation of cellular THF levels as well as in the inhibition of cell proliferation (as 10-FTHF is essential for the synthesis of purine). In addition, the overexpression of ALDH1L1 can restrict cell proliferation in vitro.

    UniProt

    O75891
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