Recombinant Acetyl-CoA Carboxylase alpha 抗体
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Quick Overview for Recombinant Acetyl-CoA Carboxylase alpha 抗体 (ABIN7879860)
抗原
See all Acetyl-CoA Carboxylase alpha (ACACA) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ACACA Antibody / Acetyl CoA Carboxylase 1
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Acetyl Coenzyme A Carboxylase was used as the immunogen for the ACACA antibody.
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亚型
- IgG
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anti-Acetyl-CoA Carboxylase alpha (ACACA) antibody
ACACA 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) (pSer79) antibodyKD Validated ACACA 适用: 人 WB, IF (p) 宿主: 兔 Monoclonal 25GB2275 unconjugated Recombinant Antibody
anti-Acetyl-CoA Carboxylase alpha (ACACA) (pSer79) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) (N-Term) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) antibodyACACA 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) antibodyKD Validated ACACA 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB5645 unconjugated Recombinant Antibody
anti-Acetyl-CoA Carboxylase alpha (ACACA) (Ser122) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) (AA 1-99) antibodyACACA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6H5 unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) (pSer80) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ACACA antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the ACACA antibody at -20oC.
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- Acetyl-CoA Carboxylase alpha (ACACA)
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别名
- ACACA
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背景
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ACACA antibody detects Acetyl CoA carboxylase 1, encoded by the ACACA gene. Acetyl CoA carboxylase 1 is a biotin dependent enzyme that catalyzes the conversion of acetyl CoA to malonyl CoA, the rate limiting step of fatty acid biosynthesis. ACACA antibody provides researchers with a specific reagent to study lipid metabolism, metabolic disease, and cancer biology.
Acetyl CoA carboxylase 1 functions by adding a carboxyl group to acetyl CoA, producing malonyl CoA, which serves as the building block for fatty acid elongation. Research using ACACA antibody has demonstrated that this enzyme is highly expressed in lipogenic tissues such as liver and adipose tissue. By controlling malonyl CoA levels, Acetyl CoA carboxylase 1 regulates lipid synthesis and contributes to energy balance.
Studies with ACACA antibody have revealed that Acetyl CoA carboxylase 1 is subject to complex regulation. It is activated by citrate, which reflects nutrient abundance, and inhibited by phosphorylation through AMP activated protein kinase under energy stress conditions. This ensures that fatty acid synthesis occurs only when energy is sufficient. Hormones such as insulin also stimulate Acetyl CoA carboxylase 1 activity, further linking the enzyme to metabolic signaling pathways.
Dysregulation of Acetyl CoA carboxylase 1 has been associated with obesity, diabetes, and cancer. Research using ACACA antibody has shown that elevated activity promotes lipid accumulation and insulin resistance, while inhibition of the enzyme improves metabolic outcomes in animal models. In cancer, increased Acetyl CoA carboxylase 1 expression supports tumor growth by fueling lipid synthesis required for membrane production and signaling. These findings highlight its therapeutic potential in both metabolic and oncologic diseases.
ACACA antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full length protein and phosphorylated forms, immunohistochemistry demonstrates tissue distribution in metabolic organs, and immunofluorescence shows cytoplasmic localization associated with lipid droplets. These applications make ACACA antibody indispensable for metabolic research.
By supplying validated ACACA antibody reagents, NSJ Bioreagents supports studies into lipid metabolism, metabolic disease, and cancer biology. Detection of Acetyl CoA carboxylase 1 provides insight into how lipid synthesis contributes to physiology and pathology. -
UniProt
- Q13085
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途径
- AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effect
抗原
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