Recombinant DPYSL2 抗体 (pThr514)
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Quick Overview for Recombinant DPYSL2 抗体 (pThr514) (ABIN7879800)
抗原
See all DPYSL2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pThr514
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原理
- Phospho-CRMP2 (Thr514) Antibody / Collapsin response mediator protein 2
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Phospho-CRMP2 (T514) was used as the immunogen for the Phospho-CRMP2 (Thr514) antibody.
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亚型
- IgG
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anti-Dihydropyrimidinase-Like 2 (DPYSL2) (C-Term) antibody
DPYSL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 470-571) antibodyDPYSL2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1F11 unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 1-572) antibodyDPYSL2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) antibodyDPYSL2 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 400-500) antibodyKO Validated DPYSL2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (C-Term) antibodyDPYSL2 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 463-492) antibodyDPYSL2 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 33CT11-40-3 unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 480-529) antibodyDPYSL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (Thr509) antibodyDPYSL2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) antibodyKD Validated DPYSL2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2985 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Phospho-CRMP2 (Thr514) antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Phospho-CRMP2 (Thr514) antibody at -20oC.
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- DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))
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别名
- CRMP2
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背景
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Phospho-CRMP2 (Thr514) antibody detects collapsin response mediator protein 2 when phosphorylated at threonine 514. CRMP2, encoded by the DPYSL2 gene, is a cytosolic phosphoprotein that regulates axon guidance, neuronal polarity, and microtubule dynamics. Phosphorylation at Thr514, primarily mediated by GSK3 beta, reduces CRMP2 binding to tubulin and destabilizes microtubules. This modification plays critical roles in neuronal development and synaptic remodeling.
Phospho-CRMP2 (Thr514) antibody is widely applied in neuroscience research, particularly in studies of axon guidance and neurodegeneration. By detecting phosphorylated CRMP2, researchers can distinguish between active and inhibited states of the protein. Elevated phosphorylation of CRMP2 at Thr514 has been associated with Alzheimer disease and other neurodegenerative conditions where microtubule stability is compromised.
The antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence. In western blot assays, Phospho-CRMP2 (Thr514) antibody detects distinct phosphorylated isoforms. Immunohistochemistry highlights tissue specific phosphorylation patterns in brain regions, while immunofluorescence enables visualization of phospho CRMP2 at growth cones and synapses. These applications make the antibody valuable for developmental neuroscience and disease studies.
Phosphorylation of CRMP2 at Thr514 regulates not only axonal outgrowth but also dendritic spine morphology and synaptic plasticity. Dysregulation of this site contributes to cognitive decline and neuropsychiatric disorders. By applying Phospho-CRMP2 (Thr514) antibody, scientists can explore mechanisms linking abnormal phosphorylation to neuronal dysfunction and identify therapeutic approaches that target CRMP2 signaling.
Phospho-CRMP2 (Thr514) antibody from NSJ Bioreagents provides reliable specificity for detecting phosphorylated DPYSL2, enabling accurate monitoring of microtubule regulatory pathways in health and disease. -
UniProt
- Q16555
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途径
- Regulation of Cell Size
抗原
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