Recombinant PKD2 抗体 (pSer876)
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Quick Overview for Recombinant PKD2 抗体 (pSer876) (ABIN7879775)
抗原
See all PKD2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer876
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原理
- Phospho-Protein Kinase D2 (Ser876) Antibody / PRKD2
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Phospho-Protein Kinase D2 (S876) was used as the immunogen for the Phospho-Protein Kinase D2 (Ser876) antibody.
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亚型
- IgG
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anti-Protein Kinase D2 (PKD2) antibody
PKD2 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) (AA 1-110) antibodyPKD2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2E4 unconjugated
anti-Protein Kinase D2 (PKD2) antibodyPKD2 适用: 人, 大鼠, 猴, 犬 WB, IF, FACS 宿主: 小鼠 Monoclonal 3F7 unconjugated
anti-Protein Kinase D2 (PKD2) (AA 829-878) antibodyPKD2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) (Internal Region) antibodyPKD2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) (N-Term) antibodyPKD2 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) (pSer876) antibodyPKD2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) antibodyPKD2 适用: 人, 大鼠, 猴, 犬 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 5G1 unconjugated
anti-Protein Kinase D2 (PKD2) (AA 556-590) antibodyPKD2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB56308 unconjugated
anti-Protein Kinase D2 (PKD2) (pSer876) antibodyPKD2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Phospho-Protein Kinase D2 (Ser876) antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Phospho-Protein Kinase D2 (Ser876) antibody at -20oC.
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- PKD2 (Protein Kinase D2 (PKD2))
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别名
- Protein Kinase D2
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背景
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Phospho-Protein kinase D2 (Ser876) antibody detects Protein kinase D2 phosphorylated at serine 876, encoded by the PRKD2 gene. Protein kinase D2 is a member of the protein kinase D family of serine threonine kinases that integrate signals from diacylglycerol, protein kinase C, and G protein coupled receptors. Phosphorylation at serine 876 is a critical regulatory event required for full catalytic activity. Phospho-Protein kinase D2 (Ser876) antibody provides researchers with a precise tool to study PRKD2 signaling in cell proliferation, migration, and inflammation.
Protein kinase D2 plays a central role in diverse cellular pathways, including vesicle trafficking, oxidative stress responses, and cytoskeletal remodeling. Studies with Phospho-Protein kinase D2 (Ser876) antibody have shown that phosphorylation at serine 876 occurs within the activation loop of the kinase domain, stabilizing active conformations and promoting downstream signaling. Activation of PRKD2 influences nuclear factor kappa B activity, gene expression, and secretion of cytokines. This modification thus represents a key regulatory switch linking extracellular signals to transcriptional responses.
PRKD2 has been implicated in oncogenesis, cardiovascular disease, and immune regulation. Research using Phospho-Protein kinase D2 (Ser876) antibody has revealed that hyperactivation of PRKD2 promotes tumor growth, angiogenesis, and metastasis by stimulating survival and motility pathways. In the cardiovascular system, phosphorylation of PRKD2 influences contraction, vascular permeability, and stress responses. Its role in immune signaling involves regulation of T cell receptor pathways and cytokine secretion. The breadth of these functions underscores the importance of monitoring phosphorylation status.
Beyond physiological roles, PRKD2 has become a potential therapeutic target. Small molecule inhibitors that block PRKD activation have been investigated in preclinical cancer and inflammatory models. Phospho-Protein kinase D2 (Ser876) antibody is a valuable tool in assessing drug effects by specifically detecting activation state. Such reagents allow researchers to dissect how therapies modulate phosphorylation dependent PRKD2 signaling and how this impacts cellular outcomes.
Phospho-Protein kinase D2 (Ser876) antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes phosphorylated from total PRKD2, while immunohistochemistry reveals activation patterns in tissue samples. Immunofluorescence demonstrates dynamic localization changes upon stimulation, providing insight into subcellular distribution of active kinase. These applications make the antibody essential for signaling research.
By supplying validated Phospho-Protein kinase D2 (Ser876) antibody reagents, NSJ Bioreagents supports studies of kinase regulation, cancer, and cardiovascular disease. Detection of phosphorylation at serine 876 provides insight into mechanisms of signal transduction and their dysregulation in pathology. -
UniProt
- Q9BZL6
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途径
- cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
抗原
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