Recombinant UBTF 抗体 (pSer484)
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北京 101111
Quick Overview for Recombinant UBTF 抗体 (pSer484) (ABIN7879748)
抗原
See all UBTF 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer484
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原理
- Phospho-UBF1 (Ser484) Antibody / Upstream-binding factor 1
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Phospho-UBF1 (S484) was used as the immunogen for the Phospho-UBF1 (Ser484) antibody.
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亚型
- IgG
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anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) (AA 551-650) antibody
UBTF 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 6B6 unconjugated
anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) (AA 551-650) antibodyUBTF 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 1A2 unconjugated
anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) (AA 551-650) antibodyUBTF 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6C6 unconjugated
anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) (Internal Region) antibodyUBTF 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) (AA 551-651) antibodyUBTF 适用: 人, 大鼠 WB, ELISA, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 1A2 unconjugated
anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) (AA 551-651) antibodyUBTF 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 2D8 unconjugated
anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) (AA 200-440) antibodyUBTF 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) (pSer484) antibodyUBTF 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) (Internal Region) antibodyUBTF 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) antibodyUBTF 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB1555 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Phospho-UBF1 (Ser484) antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Phospho-UBF1 (Ser484) antibody at -20oC.
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- UBTF (Upstream Binding Transcription Factor, RNA Polymerase I (UBTF))
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别名
- UBF1
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背景
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Phospho-UBF1 (Ser484) antibody recognizes upstream binding factor 1 phosphorylated at serine 484, a modification critical for ribosomal RNA transcription. UBF1 is a nucleolar transcription factor that binds rDNA promoters and recruits RNA polymerase I machinery to initiate rRNA synthesis. Phosphorylation at Ser484 is mediated by signaling kinases such as ERK and enhances UBF1 activity, thereby linking growth factor signaling to ribosome biogenesis.
Research employing Phospho-UBF1 (Ser484) antibody has highlighted its role in cell growth and proliferation. Enhanced UBF1 phosphorylation correlates with increased ribosome production in rapidly dividing cells, including cancer cells, where heightened protein synthesis supports tumor growth. Conversely, reduced phosphorylation is associated with decreased rRNA transcription during cellular stress or growth arrest, making Ser484 phosphorylation a sensitive marker of nucleolar activity.
Antibodies specific for phospho-UBF1 at Ser484 are useful in assays such as western blot, immunofluorescence, and chromatin immunoprecipitation. These reagents allow researchers to study how signaling pathways regulate ribosome synthesis and how nucleolar activity adapts to physiological conditions. Clone-based validation ensures that detection is specific to the phosphorylated form rather than total UBF1.
NSJ Bioreagents offers this Phospho-UBF1 (Ser484) antibody to aid in research on transcriptional regulation, signal transduction, and cancer biology. Alternate names include upstream binding factor 1 antibody, nucleolar transcription factor 1 antibody, and NOR-90 antibody. -
UniProt
- P17480
抗原
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