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Recombinant MPRIP 抗体 (pSer232)

Name: Recombinant MPRIP 抗体 (pSer232)
SKU: ABIN7879721
Availability: OutOfStock

This 兔单克隆 antibody specifically detects MPRIP in WB. It exhibits reactivity toward 小鼠和大鼠.

产品编号 ABIN7879721

发货至: 中国

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Quick Overview for Recombinant MPRIP 抗体 (pSer232) (ABIN7879721)

抗原

See all MPRIP 抗体

MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

抗体类型

Recombinant Antibody

适用

小鼠, 大鼠

宿主

兔

克隆类型

单克隆

标记

This MPRIP antibody is un-conjugated

应用范围

Western Blotting (WB)

克隆位点

31R36

Discover our top product MPRIP Primary Antibody

抗原表位
8

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1
pSer232

原理

Phospho-RIP3 (Ser232) Antibody / RIPK3

纯化方法

Affinity chromatography

免疫原

A synthesized peptide derived from human Phospho-RIP3 (S232) was used as the immunogen for the Phospho-RIP3 (Ser232) antibody.

亚型

IgG
anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (AA 473-486) antibody
MPRIP 适用: 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (C-Term) antibody
MPRIP 适用: 人, 小鼠, 大鼠 WB, ELISA, IP, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (AA 723-772) antibody
MPRIP 适用: 人, 小鼠, 大鼠 IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (AA 771-820) antibody
MPRIP 适用: 人, 小鼠, 大鼠, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (AA 550-600) antibody
MPRIP 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (AA 400-450) antibody
MPRIP 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (Center) antibody
MPRIP 适用: 人, 小鼠, 大鼠, Cow, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (N-Term) antibody
MPRIP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (pSer227) antibody
MPRIP 适用: 人 WB, IHC, IP 宿主: 小鼠 Monoclonal P2-A11 unconjugated Recombinant Antibody

anti-Myosin Phosphatase rho Interacting Protein (MPRIP) (pSer202) antibody
MPRIP 适用: 人 WB, IHC, IP 宿主: 小鼠 Monoclonal P3-28 unconjugated Recombinant Antibody

应用备注

Optimal dilution of the Phospho-RIP3 (Ser232) antibody should be determined by the researcher.

限制

仅限研究用
状态

Liquid

缓冲液

Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store the Phospho-RIP3 (Ser232) antibody at -20oC.
抗原

MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

别名

RIP3

背景

Phospho-RIP3 (Ser232) antibody detects RIP3 phosphorylated at serine 232, encoded by the RIPK3 gene. RIP3, also called Receptor interacting serine threonine kinase 3, is a critical mediator of necroptosis, a regulated form of necrotic cell death. Phospho-RIP3 (Ser232) antibody provides researchers with a specific reagent to study necroptotic signaling, inflammation, and disease mechanisms involving programmed necrosis.

RIP3 functions as a core signaling kinase within the necrosome complex. Research using Phospho-RIP3 (Ser232) antibody has shown that phosphorylation at Ser232 is essential for RIP3 activation and subsequent recruitment of MLKL, the executioner protein of necroptosis. This phosphorylation serves as a molecular switch controlling progression of the necroptotic pathway.

Studies with Phospho-RIP3 (Ser232) antibody have revealed that necroptosis is triggered by tumor necrosis factor signaling, viral infection, and cellular stress conditions. RIP3 phosphorylation at Ser232 enables necrosome assembly, MLKL oligomerization, and disruption of plasma membrane integrity. This process releases intracellular contents that amplify inflammation and immune responses.

In disease contexts, dysregulated necroptosis contributes to pathology. Research using Phospho-RIP3 (Ser232) antibody has shown that excessive activation promotes tissue damage in conditions such as ischemia reperfusion injury, inflammatory bowel disease, and neurodegeneration. Conversely, insufficient necroptosis facilitates viral persistence and impaired immune clearance. These findings highlight RIP3 phosphorylation as a therapeutic target for modulating necroptotic signaling.

Phospho-RIP3 (Ser232) antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes phosphorylated RIP3 from total levels, immunohistochemistry localizes activated necroptotic signaling in tissue, and immunofluorescence reveals subcellular distribution during necrosome formation. These applications make the antibody valuable in cell death research.

By providing validated Phospho-RIP3 (Ser232) antibody reagents, NSJ Bioreagents supports studies into programmed necrosis, inflammation, and therapeutic modulation. Detection of RIP3 phosphorylated at Ser232 provides insight into the molecular regulation of necroptosis and its contribution to disease.

UniProt

Q9Y572