Pcp2 抗体 (N-Term)
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Quick Overview for Pcp2 抗体 (N-Term) (ABIN7879647)
抗原
See all Pcp2 (PCP2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- PCP2 Antibody / Purkinje cell protein 2
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human PCP2 was used as the immunogen for the PCP2 antibody.
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亚型
- IgG
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anti-Purkinje Cell Protein 2 (PCP2) (AA 91-125) antibody
PCP2 适用: 人 WB 宿主: 兔 Polyclonal RB49334 unconjugated
anti-Purkinje Cell Protein 2 (PCP2) (N-Term) antibodyPCP2 适用: 小鼠, 人, 大鼠, Cow, 犬, 豚鼠, 马, Pig, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Purkinje Cell Protein 2 (PCP2) (AA 13-41), (N-Term) antibodyPCP2 适用: 小鼠 IHC (p) 宿主: 兔 Polyclonal RB7194 unconjugated
anti-Purkinje Cell Protein 2 (PCP2) (AA 91-120), (C-Term) antibodyPCP2 适用: 小鼠 IHC (p) 宿主: 兔 Polyclonal RB7196 unconjugated
anti-Purkinje Cell Protein 2 (PCP2) (N-Term) antibodyPCP2 适用: 小鼠, 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Purkinje Cell Protein 2 (PCP2) (N-Term) antibodyPCP2 适用: 小鼠, 人, 大鼠, Cow, 犬, 豚鼠, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PCP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PCP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Pcp2 (PCP2) (Purkinje Cell Protein 2 (PCP2))
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别名
- PCP2
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背景
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PCP2 antibody detects Purkinje cell protein 2, a brain-specific regulator of G protein signaling and neuronal function. Encoded by the PCP2 gene on chromosome 19p13.2, this protein is selectively expressed in cerebellar Purkinje cells and retinal bipolar neurons. PCP2, also known as L7, modulates intracellular signaling by binding to Galpha subunits of heterotrimeric G proteins, influencing synaptic transmission and motor coordination.
PCP2 contains a GoLoco motif that enables high-affinity binding to inactive GDP-bound Galpha subunits, acting as a guanine nucleotide dissociation inhibitor (GDI). Through this interaction, it regulates G protein-coupled receptor (GPCR) signaling pathways that affect neuronal excitability and neurotransmitter release. PCP2 expression increases during cerebellar development, coinciding with synapse formation and maturation of Purkinje cells.
The PCP2 antibody is widely used in neurobiology, developmental, and signaling research to investigate cerebellar function, G protein regulation, and neuronal connectivity. Western blot analysis identifies a 17 kilodalton band corresponding to PCP2, while immunohistochemistry shows intense staining in Purkinje cell somata and dendrites, as well as retinal bipolar neurons. This antibody enables precise visualization of neuronal subtypes and signaling dynamics in the cerebellum and retina.
Altered expression of PCP2 has been associated with ataxia, autism spectrum disorders, and visual processing abnormalities, reflecting its role in synaptic signal modulation. The PCP2 antibody provides a sensitive tool for exploring cerebellar physiology and G protein regulation. NSJ Bioreagents validates this antibody for its applications, ensuring robust detection for neuroscience applications. -
UniProt
- Q8IVA1
抗原
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